Abstract
Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than 90% of non-small (NSCLCs) cell lung cancers. In addition, these changes appear early in the pathogenesis of lung cancer and are found as clonal lesions in the smoking damaged respiratory epithelium including histologically normal epithelium as well as in epithelium showing histologic changes of preneoplasia. These 3p genetic alterations lead to the conclusion that the short arm of human chromosome 3 contains several tumor suppressor gene(s) (TSG(s)). Although the first data suggesting that 3p alterations were involved in lung carcinogenesis were published more than 10 years ago, only recently has significant progress been achieved in identifying the candidate TSGs and beginning to demonstrate their functional role in tumor pathogenesis. Some of the striking results of these findings has been the discovery of multiple 3p TSGs and the importance of tumor acquired promoter DNA methylation as an epigenetic mechanism for inactivating the expression of these genes in lung cancer. This progress, combined with the well known role of smoking as an environmental causative risk factor in lung cancer pathogenesis, is leading to the development of new diagnostic and therapeutic strategies which can be translated into the clinic to combat and prevent the lung cancer epidemic. It is clear now that genetic and epigenetic abnormalities of several genes residing in chromosome region 3p are important for the development of lung cancers but it is still obscure how many of them exist and which of the numerous candidate TSGs are the key players in lung cancer pathogenesis. We review herein our current knowledge and describe the most credible candidate genes.
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Abbreviations
- AI:
-
allelic imbalance
- aa:
-
amino acid
- BPDE:
-
benzo[a]pyrene diol epoxide
- CC-RCC:
-
clear cell renal cell carcinomas
- CER1:
-
common eliminated region
- FAR:
-
frequently affected with rearrangements region
- LOH:
-
loss of heterozygosity
- NSCLC:
-
non-small cell lung cancer
- RA:
-
retinoic acid
- SCLC:
-
small cell lung cancer
- TSA:
-
trichostatin-A
- TSG:
-
tumor suppressor gene
- AZA:
-
5-aza-2′-deoxycytidine
- CGH:
-
comparative genome hybridization
- SNP:
-
single nucleotide polymorphism
- FISH:
-
fluorescent in situ hybridization
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Acknowledgements
We thank the many collaborators that made up the 3p lung cancer tumor suppressor gene consortium, particularly Yoshitaka Sekido and Farida Latif for all of their hard work in the initial identification of the 3p21.3 genes. The membership of the consortium includes: University of Texas Southwestern Medical Center at Dallas, and MD Anderson Cancer Center, Houston, USA Group: Yoshitaka Sekido, Scott Bader, David Burbee, Kwun Fong, Eva Forgacs, Boning Gao, Harold Garner, Adi F Gazdar, Luc Girard, Craig Kamibayashi, Masashi Kondo, Ashwini Pande, Vivek Ramalingam, Dwight Randle, Yoshio Tomizawa, Arvind Virmani, Ivan Wistuba and John D Minna (Dallas), and Lin Ji, Bingling Fang, Neely Atkinson, and Jack A Roth (Houston). University of Birmingham, UK Group: Donia Macartney, Sofia Honorio, Eamonn Maher and Farida Latif. The Karolinska Institute, Sweden, Group: Eleonora Braga, Vladimir Kashuba, Alexei Protopopov, Vera Senchenko, Jingfeng Li, Fuli Wang, Veronika Zabarovska, George Klein, and Eugene R Zabarovsky. NCI, USA Group: (1) Fuh-Mei Duh, Ming-Hui Wei, Laura Geil, Igor Kuzmin, Sergei Ivanov, Intramural Research Support Program, SAIC Frederick, and Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702; (2) Debora Angeloni, Alla Ivanova, Bert Zbar, Michael I Lerman, Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702; (3): Bruce E Johnson, Medicine Branch at the National Naval Medical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. ER Zabarovsky was supported by research grants from the Swedish Cancer Society, the Swedish Research Council, STINT, Pharmacia Corporation and Karolinska Institute. JD Minna was supported by Lung Cancer SPORE P50 CA70907, and CA71618.
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Zabarovsky, E., Lerman, M. & Minna, J. Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 21, 6915–6935 (2002). https://doi.org/10.1038/sj.onc.1205835
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