Table 2 Hypermethylation of the POU2F3 promoter in cervical cancer cell lines and cervical tissue

From: Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer

Samples

Tumor classification

Methylation

  

Positive

Negative

Frequency of methylation (%)

Cervical cancers

 

18

28

18/46 (39%)

 

Histology a

   
 

 Adenocarcinoma

1

4

 
 

 Adenosquamous

4

5

 
 

 Squamous

13

19

 
 

HPV type a

   
 

 HPV16

7

11

 
 

 HPV18

4

9

 
 

 Other

2

5

 
 

 Multiple

5

3

 
 

Stage a

   
 

 I

16

25

 
 

 II

2

3

 
 

Lymph node metastasis a

   
 

 Positive

3

6

 
 

 Negative

10

17

 
 

 ND

5

5

 

CC cell lines

 

6

5

6/11 (54.5%)

Normal cervical epithelium

 

0

7

0/7 (0%)

  1. ND: not determined.
  2. aThe methylation of POU2F3 CpG sites did not correlate statistically with clinicopathological features such as tumor histology, HPV type, stage and lymph node metastasis (P>0.05).
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