Table 1 Papilloma incidence in the congenic lines

Congenic line	Chromosomal region (cM) ^a	Backcross			Intercross
		NS ^b	NN ^b	P-value^c	SS ^b	NN ^b	P-value^c
3540	15.4–28.9	12.5 (1–33; n=20)	22 (4–38; n=18)	2.4E-03	6 (1–21; n=14)	15 (2–28; n=20)	8.0E-04
A62	18–28.9	11 (0–32; n=19)	22 (4–36; n=19)	2.1E-03	4 (0–19; n=16)	15 (2–32; n=15)	5.3E-04
717	18–21.8	14 (0–32; n=17)	24 (14–35; n=13)	1.5E-03	6 (0–19; n=17)	15 (4–27; n=19)	1.9E-04
B6F	18–19.3	17 (5–31; n=12)	20 (5–41; n=14)	0.16	14 (0–36; n=17)	14 (4–28; n=16)	0.40
C3F	20.9–28.9	6.5 (0–29; n=12)	22.5 (4–36; n=18)	4.6E-03	2 (0–11; n=13)	17 (4–32; n=16)	2.9E-05
454	25.4–28.9	20 (2–37; n=13)	23 (6–41; n=19)	0.24	15 (2–28; n=16)	12 (1–27; n=23)	0.19
314	27.6–28.9	18.5 (4–34; n=8)	23 (6–36; n=11)	0.15	ND	ND	ND
D0F	1.7–19.3	ND	ND	ND	10 (1–21; n=19)	14.5 (1–31; n=22)	0.03
150	15.4–17	ND	ND	ND	10 (1–20; n=17)	15 (2–33; n=17)	0.03
260	15.4–18	ND	ND	ND	11 (0–20; n=16)	12 (3–24; n=26)	0.16
381	20.9–25.4	ND	ND	ND	5.5 (0–17; n=26)	14.5 (4–27; n=20)	3.7E-05
383	20.9–26.7	ND	ND	ND	1 (0–10; n=23)	13.5 (4–45; n=22)	1.4E-08
1230	20.9–21.8	ND	ND	ND	8 (0–29; n=16)	25 (20–32; n=10)	2.4E-04

Abbreviations: ND, not determined; SSLP, simple sequence length polymorphism.
^aRegion of chromosome 7 for which the congenic lines contain M. spretus alleles is indicated in cM based on the location of SSLP markers as determined with the described NIH/Ola × M. spretus backcrosses (n>1000).
^bMedian values for papilloma numbers (with range and number of mice in parenthesis) 20 weeks after tumor initiation are shown per genotype.
^cP-values for comparison of papilloma numbers in mice heterozygous NIH/Ola-M. spretus (NS; backcross) or homozygous NIH/Ola (NN, backcross), or for comparison of papilloma numbers in the reciprocal homozygotes (NN or SS) in the same congenic lines (Wilcoxon rank sum test).

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