Table 2 Homozygous deletions (log2ratio <−2.0) detected in OSCC cell lines by array-CGH analysis using MCG Cancer Array-800 and Whole Genome Array-4500

From: PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation

No

BAC

Locus a

Cell line (total 18)

Possible candidate gene b

Number of known gene

  

Chromosome band

Position

n

Name

  

1

RP11-91K6

2q24.1-q24.2

chr2:159,678,005-159,832,799

1

HO-1-N-1

None

23

2

RP11-165A20

RP11-80K21

RP11-66P13

10p12.1

chr10:25,269,606-25,426,074

chr10:25,407,097-25,570,777

chr10:26,528,582-26,697,629

1

HSC-6

None

17

  1. Abbreviations: Array-CGH, array-based comparative genomic hybridization; BAC, bacterial artificial chromosome; OSCC, oral squamous-cell carcinoma.
  2. aBased on UCSC Genome Browser, May 2004 Assembly.
  3. bGenes located around BAC, whose homozygous deletion was validated by genomic PCR.
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