Table 2 Relative Metabolic Rate in Prefrontal Cortex in Normal Subjects and Impulsive/Aggressive Patients: Fenfluramine Effect Difference

From: d,l-fenfluramine Response in Impulsive Personality Disorder Assessed with [18F]fluorodeoxyglucose Positron Emission Tomography

 

Patients

Normal Subjects

Normal Patient

 

Right

Left

Right

Left

Right

Left

Regions

Placebo

Fen

Placebo

Fen

Placebo

Fen

Placebo

Fen

Fen

Placebo

Superior dorsolateral

          

1

0.90

0.94

0.98

0.97

0.83

0.90

0.94

1.00

0.03

0.07

2

1.00

1.03

1.00

1.09

0.91

1.01

0.97

1.09

0.07

0.03

3a

1.08

1.05

1.08

1.16

0.96

1.08

1.02

1.10

0.15

0.00

4a

1.14

1.11

1.18

1.24

1.09

1.19

1.10

1.18

0.13

0.02

Mid-dorsolateral

          

5a

1.17

1.22

1.20

1.28

1.14

1.28

1.21

1.24

0.09

−0.05

6a

1.23

1.28

1.22

1.32

1.19

1.32

1.27

1.28

0.08

−0.09

7a

1.26

1.29

1.25

1.38

1.26

1.33

1.25

1.28

0.04

−0.10

8a

1.30

1.28

1.26

1.37

1.26

1.31

1.26

1.30

0.07

−0.07

Orbital lateral

          

9a

1.26

1.21

1.25

1.32

1.19

1.21

1.21

1.27

0.07

0.04

10

1.17

1.12

1.23

1.23

1.10

1.12

1.12

1.17

0.07

0.05

11b

1.08

1.07

1.11

1.05

0.98

1.01

0.99

1.09

0.04

0.16

12a

1.00

1.03

1.02

0.99

0.94

0.96

0.96

1.04

−0.01

0.05

Orbital surface

          

13a,c

0.96

1.00

0.99

0.98

0.94

0.99

0.88

0.98

0.00

0.11

14a

0.89

0.94

0.92

0.92

0.91

0.90

0.86

0.91

−0.06

0.06

15a,c

0.94

0.98

0.88

0.98

0.94

0.98

0.93

0.94

0.00

−0.08

16

0.97

0.96

0.97

0.99

0.98

1.01

0.95

1.00

0.04

0.03

  1. Omnibus test across groups; Drug condition × hemisphere × region × group interaction: F = 5.16, df = 12.4, 11, p < .0001. Drug condition × hemisphere × group interaction (F = 7.73, df = 1,9, p < .02). Data are not shown for dug condition × hemisphere × region × group × slice (F = 1.49, df = 49.8, 448, p < .01).
  2. Omnibus test in normal subjects only; Drug condition × hemisphere × regions interaction, F = 2.50, p = .056. Omnibus test in patients only: drug condition × hemisphere: F = 14.95, df = 1,9, p = .0038; drug condition × hemisphere × region interaction: F = 4.54, df = 12.4, 111.8, p < .0001.
  3. Followup ANOVA on each cortical segment from superior dorsal (1) to orbital medial (16).
  4. a Drug condition × group × hemisphere condition interaction significant for individual sector, p < .05.
  5. b Drug condition × group interaction significant.
  6. c Drug condition × hemisphere × group × anteroposterior slice significant; data not shown.
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