Abstract
IT has been demonstrated1 that ‘microcythæmia’ or ‘thalasshæmia’ depends on a single gene pair with semi-dominance. The heterozygotes Mm are microcythæmics, that is, entirely viable individuals, either normal, or suffering from a mild form of anhæmia. The homozygotes MM, on the contrary, are affected by Cooley's disease and die early in childhood. The two forms are also called by American authors ‘thalasshæmia minor’ (Mm), and ‘thalasshæmia major’ (MM).
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References
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Haldane, J. B. S., Proc. Roy. Soc., B, 135, 147 (1948).
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SILVESTRONI, E., BIANCO, I., MONTALENTI, G. et al. Frequency of Microcythæmia in some Italian Districts. Nature 165, 682–683 (1950). https://doi.org/10.1038/165682a0
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DOI: https://doi.org/10.1038/165682a0
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