Abstract
We report a case of tularemia presenting as a solitary pulmonary nodule following syngeneic PBSC transplant. Seven months after undergoing a syngeneic PBSC transplant for AML, our patient presented with fever without localizing signs. Chest X-ray revealed a solitary pulmonary nodule. Culture of a CT guided needle aspiration revealed Francisella tularensis. The patient was successfully treated with ciprofloxacin. His fever resolved and clearance of the nodule was documented on a CT scan 2 months after diagnosis and initiation of treatment. To our knowledge, this is the only reported case of tularemia occurring in the post-transplant setting. The possible relationship between transplant-induced immune dysfunction and the occurrence of this rare infection is discussed.
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Naughton, M., Brown, R., Adkins, D. et al. Tularemia – an unusual cause of a solitary pulmonary nodule in the post-transplant setting. Bone Marrow Transplant 24, 197–199 (1999). https://doi.org/10.1038/sj.bmt.1701863
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DOI: https://doi.org/10.1038/sj.bmt.1701863