Abstract
A male patient with hypereosinophilic syndrome (HES) underwent an allogeneic blood stem cell transplantation from a female donor following non-myeloablative conditioning consisting of a 2 Gy dose of TBI and fludarabine 30 mg/m2 intravenously on three days. Before transplantation 100% of the mitotic bone marrow cells of the patient showed a clonal karyotype abnormality. Three months after the transplantation eosinophilia had resolved and a chromosome analysis revealed normal female karyotype. The present study shows that stem cell transplantation after non-myeloablative conditioning may have curative potential for HES.
Bone Marrow Transplantation (2002) 29, 457–458. doi:10.1038/sj.bmt.1703379
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Juvonen, E., Volin, L., Koponen, A. et al. Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome. Bone Marrow Transplant 29, 457–458 (2002). https://doi.org/10.1038/sj.bmt.1703379
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DOI: https://doi.org/10.1038/sj.bmt.1703379
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