Summary:
We report three cases of massive chest wall plasmacytoma, each greater than 10 cm in diameter, without evidence of overt myeloma, whom we treated with a combination of VAD chemotherapy consolidated by high-dose melphalan and autologous peripheral blood stem cell transplantation and radical radiotherapy. All three patients completed all components of their therapy without experiencing any major side effects and one patient has had a durable remission. The other two patients have had disease progression but at sites other than the original tumour.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Tsang RW, Gospodarowicz MK, Pintilie M et al. Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome. Int J Radiat Oncol Biol Phys 2001; 50: 113–120.
Barlogie B, Smith L, Alexanian R . Effective management of advanced multiple myeloma refractory to alkylating agents. N Engl J Med 1984; 310: 1353–1356.
McQuaker IG, Haynes AP, Stainer C et al. Stem cell mobilization in resistant or relapsed lymphoma: superior yield of progenitor cells following a salvage regimen comprising ifosphamide, etoposide and epirubicin compared to intermediate-dose cyclophosphamide. Br J Haematol 1997; 98: 228–233.
Bataille R, Sany J . Solitary myeloma: clinical and prognostic factors of a review of 114 cases. Cancer 1981; 48: 845–851.
Jackson A, Scarffe JH . Prognostic significance of osteopenia and immunoparesis at presentation in patients with solitary myeloma of bone. Eur J Cancer 1990; 26: 363–371.
Leibross R, Ha C, Cox J et al. Clinical course of solitary extramedullary plasmacytoma. Radiother Oncol 1999; 52: 245–249.
Holland J, Trenkner DA, Wasserman TH, Fineberg B . Plasmacytoma. Treatment results and conversion to myeloma. Cancer 1992; 69: 1513–1517.
Avilés A, Huerta-Guzman J, Delgado S et al. Improved outcome in solitary bone plasmacytomata with combined therapy. Hematol Oncol 1996; 14: 111–117.
Vianelli N, Tosi P . The irreplaceable image: plasmacytoma with cutaneous and pleural involvement. Haematologica 1999; 84: 559.
Fernandez LA, Couban S, Sy R, Miller R . An unusual presentation of extramedullary plasmacytoma occurring sequentially in the testis, subcutaneous tissue, and heart. Am J Hematol 2001; 67: 194–196.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Das-Gupta, E., Sidra, G., Bessell, E. et al. High-dose melphalan followed by radical radiotherapy for the treatment of massive plasmacytoma of the chest wall. Bone Marrow Transplant 32, 759–761 (2003). https://doi.org/10.1038/sj.bmt.1704221
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1704221
Keywords
This article is cited by
-
Extramedullary Plasmacytoma Involving the Abdominal Vessels and Pancreas
Digestive Diseases and Sciences (2007)