Summary:
The relation between thyroid hormone changes and cytokines in bone marrow transplantation (BMT) patients has not been studied. This prospective study was designed to determine the relation between thyroid hormones and cytokine levels after BMT and their effects on the mortality. We studied 80 patients undergoing allogeneic BMT. Serum thyroid hormone parameters and cytokine levels were measured before and serially during 6 months after BMT. Serum T3 decreased to a nadir 3 weeks post-BMT and serum T4 was lowest at 3 months post-BMT. Serum thyroid stimulating hormone (TSH) sharply decreased to a nadir at 1 week and recovered. Serum interleukin-6 increased for 2 weeks after BMT and declined thereafter. Serum tumor necrosis factor-α increased for 3 weeks after BMT and declined thereafter. After 3 weeks post-BMT, both cytokine levels were negatively correlated with serum T3 and T4 levels. A total of 29 patients died before 1 year post-BMT and 51 patients survived longer than 1 year. Those patients who died before 1 year post-BMT had significantly lower levels of T4 at 3 weeks, 3 and 6 months than surviving patients. In conclusion, increased levels of serum IL-6 and TNF-α were negatively correlated with thyroid hormone concentrations in BMT recipients suggesting the role of these cytokines in euthyroid sick syndrome.
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Acknowledgements
Cytokines determinations were made by Dr Hack-Joo Kim and Dr Young-Hoon Suh (Hyundai Research Institute, Hyundai Pharmaceutical Co., Incheon, Korea) and their help is gratefully acknowledged. This study was supported by the grant from the Korean Ministry of Health and Welfare (01-PJ1-PG1-01CH08-0001) and the Samsung Grant #SBRI C-A3-223-1.
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Lee, W., Kang, M., Oh, K. et al. Relationship between circulating cytokine levels and thyroid function following bone marrow transplantation. Bone Marrow Transplant 33, 93–98 (2004). https://doi.org/10.1038/sj.bmt.1704304
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DOI: https://doi.org/10.1038/sj.bmt.1704304
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