Abstract
Pancreatitis is a well-recognized consequence of blood and marrow transplantation (BMT). In a 4-year period, between January 2001 and December 2004, five children who received a BMT in our institution were diagnosed as having pancreatitis. Four of these five children also had adenoviral infection. We report these four cases and highlight the importance of investigating for pancreatitis patients who have any abdominal symptoms post BMT, and include specific stool culture for viral isolation, if it is not already known.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Howard DS, Phillips II GL, Reece DE, Munn RK, Henslee-Downey J, Pittard M et al. Adenovirus infections in hematopoietic stem cell transplant recipients. Clin Infect Dis 1999; 29: 1494–1501.
Flomenberg P, Babbitt J, Drobyski WR, Ash RC, Carrigan DR, Sedmak GV et al. Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis 1994; 169: 775–781.
Shields AF, Hackman RC, Fife KH, Corey L, Meyers JD . Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med 1985; 312: 529–533.
Hale GA, Heslop HE, Krance RA, Brenner MA, Jayawardene D, Srivastava DK et al. Adenovirus infection after pediatric bone marrow transplantation [Review] [34 refs]. Bone Marrow Transplant 1999; 23: 277–282.
Baldwin A, Kingman H, Darville M, Foot AB, Grier D, Cornish JM et al. Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant 2000; 26: 1333–1338.
La Rosa AM, Champlin RE, Mirza N, Gajewski J, Giralt S, Rolston KV et al. Adenovirus infections in adult recipients of blood and marrow transplants. Clin Infect Dis 2001; 32: 871–876.
Runde V, Ross S, Trenschel R, Lagemann E, Basu O, Renzing-Kohler K et al. Adenoviral infection after allogeneic stem cell transplantation (SCT): report on 130 patients from a single SCT unit involved in a prospective multi center surveillance study. Bone Marrow Transplant 2001; 28: 51–57.
Kampmann B, Cubitt D, Walls T, Naik P, Depala M, Samarasinghe S et al. Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation. Br J Haematol 2005; 130: 595–603.
Ljungman P, Gleaves CA, Meyers JD . Respiratory virus infection in immunocompromised patients. Bone Marrow Transplant 1989; 4: 35–40.
Miyamura K, Takeyama K, Kojima S, Minami S, Matsuyama K, Morishima Y et al. Hemorrhagic cystitis associated with urinary excretion of adenovirus type 11 following allogeneic bone marrow transplantation. Bone Marrow Transplant 1989; 4: 533–535.
Yolken RH, Bishop CA, Townsend TR, Bolyard EA, Bartlett J, Santos GW et al. Infectious gastroenteritis in bone-marrow-transplant recipients. N Engl J Med 1982; 306: 1010–1012.
Johnson PR, Yin JA, Morris DJ, Desai M, Cinkotai KI, McKeogh MM . Fulminant hepatic necrosis caused by adenovirus type 5 following bone marrow transplantation. Bone Marrow Transplant 1990; 5: 345–347.
Liles WC, Cushing H, Holt S, Bryan C, Hackman RC . Severe adenoviral nephritis following bone marrow transplantation: successful treatment with intravenous ribavirin. Bone Marrow Transplant 1993; 12: 409–412.
Niemann TH, Trigg ME, Winick N, Penick GD . Disseminated adenoviral infection presenting as acute pancreatitis. Hum Pathol 1993; 24: 1145–1148.
Davis D, Henslee PJ, Markesbery WR . Fatal adenovirus meningoencephalitis in a bone marrow transplant patient. Ann Neurol 1988; 23: 385–389.
Hierholzer JC . Adenoviruses in the immunocompromised host [Review] [141 refs]. Clin Microbiol Rev 1992; 5: 262–274.
Foulis AK, Farquharson MA, Sale GE . The pancreas in acute graft versus host disease in man. Histopathology 1989; 14: 121–128.
Klassen DK, Drachenberg CB, Papadimitriou JC, Cangro CB, Fink JC, Bartlett ST et al. CMV allograft pancreatitis: diagnosis, treatment, and histological features. Transplantation 2000; 69: 1968–1971.
Schiller GJ, Nimer SD, Gajewski JL, Golde DW . Abdominal presentation of varicella–zoster infection in recipients of allogeneic bone marrow transplantation [see comment]. Bone Marrow Transplant 1991; 7: 489–491.
Ljungman P, Ribaud P, Eyrich M, Matthes-Martin S, Einsele H, Bleakley M et al. Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 2003; 31: 481–486.
Schleuning M, Buxbaum-Conradi H, Jager G, Kolb HJ . Intravenous ribavirin for eradication of respiratory syncytial virus (RSV) and adenovirus isolates from the respiratory and/or gastrointestinal tract in recipients of allogeneic hematopoietic stem cell transplants. Hematol J 2004; 5: 135–144.
Bordigoni P, Carret AS, Venard V, Witz F, Le Faou A . Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 2001; 32: 1290–1297.
Ribaud P, Scieux C, Freymuth F, Morinet F, Gluckman E . Successful treatment of adenovirus disease with intravenous cidofovir in an unrelated stem-cell transplant recipient. Clin Infect Dis 1999; 28: 690–691.
Kapelushnik J, Or R, Delukina M, Nagler A, Livni N, Engelhard D . Intravenous ribavirin therapy for adenovirus gastroenteritis after bone marrow transplantation. J Pediatr Gastroenterol Nutr 1995; 21: 110–112.
Mallory A, Kern Jr F . Drug-induced pancreatitis: a critical review [Review] [91 refs]. Gastroenterology 1980; 78: 813–820.
Sastry J, Young S, Shaw PJ . Acute pancreatitis due to tacrolimus in a case of allogeneic bone marrow transplantation. Bone Marrow Transplant 2004; 33: 867–868.
Werlin SL, Casper J, Antonson D, Calabro C . Pancreatitis associated with bone marrow transplantation in children. Bone Marrow Transplant 1992; 10: 65–69.
Shore T, Bow E, Greenberg H, Persad R, Patterson D, Rubinger M et al. Pancreatitis post-bone marrow transplantation. Bone Marrow Transplant 1996; 17: 1181–1184.
Ko CW, Gooley T, Schoch HG, Myerson D, Hackman RC, Shulman HM et al. Acute pancreatitis in marrow transplant patients: prevalence at autopsy and risk factor analysis. Bone Marrow Transplant 1997; 20: 1081–1086.
Werlin SL . Acute pancreatitis. In: Richard E, Behrman, Robert Kliegman, Hal B Jenson (eds). Nelson Textbook of Pediatrics, 17th edn. 2005, pp 1300–1302.
Shifrin AL, Chirmule N, Gao GP, Wilson JM, Raper SE . Innate immune responses to adenoviral vector-mediated acute pancreatitis. Pancreas 2005; 30: 122–129.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bateman, C., Kesson, A. & Shaw, P. Pancreatitis and adenoviral infection in children after blood and marrow transplantation. Bone Marrow Transplant 38, 807–811 (2006). https://doi.org/10.1038/sj.bmt.1705526
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1705526
Keywords
This article is cited by
-
A scoping review on acute gastrointestinal surgical complications in immunocompromised pediatric patients
Annals of Pediatric Surgery (2022)
-
Acute pancreatitis following allogeneic hematopoietic stem cell transplantation in children
International Journal of Hematology (2021)
-
Pancreatitis in children and adolescents
Current Gastroenterology Reports (2008)