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A Possible Intermediate in the Biosynthesis of Tryptophan: I-Deoxy-I-N-o-Carboxyphenyl-Ribulose

Nature volume 181, pages 549–550 (1958)Cite this article

Abstract

DURING an investigation of compounds formed by washed cell suspensions of mutant strains of Aerobacter aerogenes blocked at various stages in tryptophan synthesis, two strains (N3–33 and N2–18) were found to form a compound which showed an intense blue-violet fluorescence under ultra-violet light, but the absorption spectrum of which did not correspond to any known compound. Neither strain of A. aerogenes would grow in the minimal medium described by Davis and Mingioli1 unless either tryptophan or indole was added and they were therefore presumably unable to convert anthranilic acid to indole.

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References

  1. Davis, B. D., and Mingioli, E. S., J. Bact., 60, 17 (1950).

    CAS  Google Scholar 

  2. Gibson, F., Jones, M. J., and Teltscher, H., Biochem. J., 64, 132 (1956).

    Article  CAS  Google Scholar 

  3. Yanofsky, C., J. Biol. Chem., 223, 171 (1956).

    CAS  PubMed  Google Scholar 

  4. Hodge, J. E., “Adv. Carbohydrate Chem.”, 10, 169 (1955).

    CAS  Google Scholar 

  5. Gibson, F., and Jones, M. J., Aust. J. Sci., 17, 33 (1954).

    Google Scholar 

  6. Aronoff, S., and Vernon, L., Arch. Biochem., 28, 424 (1950).

    CAS  PubMed  Google Scholar 

  7. Aronoff, S., “Techniques of Radiobiochemistry” (Iowa State College Press, Ames, 1956).

    Google Scholar 

  8. Borenfreund, E., and Dische, Z., Arch. Biochem. Biophys., 67, 239 (1957).

    Article  CAS  Google Scholar 

  9. Johanson, R., Nature, 172, 956 (1953).

    Article  ADS  CAS  Google Scholar 

  10. Trevelyan, W. E., Procter, D. P., and Harrison, J. S., Nature, 166, 444 (1950).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Bacteriology School, University of Melbourne,

    F. W. E. GIBSON, C. H. DOY & SHELAGH B. SEGALL

Authors
  1. F. W. E. GIBSON
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  2. C. H. DOY
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  3. SHELAGH B. SEGALL
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GIBSON, F., DOY, C. & SEGALL, S. A Possible Intermediate in the Biosynthesis of Tryptophan: I-Deoxy-I-N-o-Carboxyphenyl-Ribulose. Nature 181, 549–550 (1958). https://doi.org/10.1038/181549a0

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