Abstract
IN the alkali denaturation method of Singer, Chernoff and Singer1 the one-minute residue of normal adult hæmoglobin gives a spectrophotometric reading of 0.5–1.8 per cent ‘alkali resistant hæmoglobin’. It is well known1,2,3, that most of this residue is not true fœtal hæmoglobin, but some other hæm-compound, the nature of which is unknown.
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References
Singer, K., Chernoff, A. I., and Singer, L., Blood, 6, 413 (1951).
Huisman, T. H. J., Jonxis, J. H. P., and Dozy, A., Biochim. Biophys. Acta, 18, 576 (1955).
Beaven, G. H., Ellis, M., and White, J. C., Nature, 178, 857 (1956).
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BETKE, K., MARTI, H. & SCHLICHT, I. Estimation of Small Percentages of Fœtal Hæmoglobin. Nature 184, 1877–1878 (1959). https://doi.org/10.1038/1841877a0
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DOI: https://doi.org/10.1038/1841877a0
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