Abstract
THE immersion of frog muscle in Ringer solution, with a high potassium content, is known to cause a decrease in the resting potential of the fibres accompanied by a large increase in oxygen consumption and heat production of long duration; no mechanical change of muscle is observed in these conditions. A possible cause of this effect was discussed by Hill and Howarth1, and a hypothesis was suggested according to which the depolarization produced by potassium releases the catabolic processes normally accompanying contraction of muscle. Nevertheless, the whole mechanism is still very obscure.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hill, A. V., and Howarth, J. V., Proc. Roy. Soc., B, 147, 21 (1957).
Fenn, W. O., Amer. J. Physiol., 97, 635 (1931).
Nachmansohn, D., Chemical and Molecular Basis of Nerve Activity (Academic Press, London, 1959).
Van der Kloot, W. G., J. Gen. Physiol., 41, 879 (1958).
Briner, G. P., Simon, S. E., Frater, R., and Tasker, P., Biochim. Biophys. Acta, 35, 485 (1959).
Shanes, A. M., Pharmacol. Rev., 10, 59 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NOVOTNÝ, I., VYSKOČIL, F. Inhibition by Physostigmine of the Increase of Oxygen Consumption induced by Potassium in Muscle. Nature 191, 916–917 (1961). https://doi.org/10.1038/191916a0
Issue Date:
DOI: https://doi.org/10.1038/191916a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.