Abstract
Tabechian, Altman and Young1 have shown that red blood cells from patients with hereditary spherocytosis are more sensitive to fluoride than normal red blood cells with respect to the 32P-orthophosphate exchange reaction between the extra- and intra-cellular compartments. From these results they concluded that the enzymes enolase or adenosine triphosphatase are the most likely to be defective in the red blood cells of patients with hereditary spherocytosis. Prankerd2 investigated the adenosine triphosphatase activity of such cells and found this enzyme to be normally active. The possibility that the defect involves enolase is supported by some unpublished results of Altman and Young. However, glycolytic intermediates have been shown to be normal3,4. These results strongly indicate that an enzymatic defect in the Embden–Meyerhof pathway is unlikely.
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References
Tabechian, H., Altman, K. I., and Young, L. E., Proc. Soc. Exp. Biol. and Med., 92, 712 (1956).
Prankerd, T. A. J., Amer. J. Med., 22, 724 (1957).
Weinstein, I. M., Dunn, I., Coe, E. L., and Ibsen, K. H., Clin. Res., 8, 133 (1960).
Shafer, A. W., Clin. Res., 9, 67 (1961).
Braunsteiner, H., and Sailer, S., Wien, Z. Inn. Med., 42, 305 (1961).
Valentine, W. N., and Beck, W. S., J. Lab. and Clin. Med., 38, 39 (1951).
Bock, H. E., Karges, O., Löhr, G. W., and Waller, H. D., Klin. Wschr., 36, 56 (1957).
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MIWA, S., TANAKA, K. & VALENTINE, W. Enolase Activity of Erythrocytes in Hereditary Spherocytosis. Nature 195, 613–614 (1962). https://doi.org/10.1038/195613a0
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DOI: https://doi.org/10.1038/195613a0
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