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A New Metabolic Regulator : its Stimulation of Citric Acid Production and Anti-sulphon-amide and Streptomycin Effect

Abstract

ALTHOUGH at present many data are available concerning the production of citric acid by fungi1–5, very little is known of the mechanism by which the production of this acid is regulated. Its production in Aspergillus niger varies greatly with the strain and the medium6,7. The same strain, under various conditions, is capable in one case of converting practically all the sugar available into citric acid; in another case production is decreased by the conditions of the reaction practically to zero.

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References

  1. Shu, P., and Johnson, M. J., Indust. Eng. Chem., 40, 1202 (1948).

    Article  CAS  Google Scholar 

  2. Martin, S. M., Wilson, P. W., and Burris, R. H., Arch. Biochem., 26, 103 (1950).

    CAS  Google Scholar 

  3. Foster, J. W., and Carson, S. F., J. Amer. Chem. Soc., 72, 1865 (1950).

    Article  CAS  Google Scholar 

  4. Lewis, K. F., and Weinhouse, W. G., J. Amer. Chem. Soc., 73, 2906 (1951).

    Article  CAS  Google Scholar 

  5. Kornberg, H. L., and Krebs, H. A., Nature, 179, 988 (1957).

    Article  ADS  CAS  Google Scholar 

  6. Leopold, H., and Fencl, Z., Chem. Technik, 10, 507 (1958).

    CAS  Google Scholar 

  7. Zhuravskii, G. I., et al., Proizvodstvo pishchevykh kislot. (Pishchepromizdat, Moscow, 1953).

  8. Fencl, Z., and Vintrova, E., Czechoslovak Patent Application PV 2698-61.

  9. Nossal, P. M., Austral. J. Exp. Biol. Med. Sci., 31, 583 (1953).

    Article  CAS  Google Scholar 

  10. Rajagopalan, K. V., Radhakrishnamurthy, R., and Sarma, P. S., Nature, 184, 461 (1959).

    Article  ADS  CAS  Google Scholar 

  11. Novelli, G. D., and Lipmann, F., J. Biol. Chem., 182, 213 (1950).

    CAS  Google Scholar 

  12. Stern, R. J., and Ochoa, S., J. Biol. Chem., 179, 491 (1949).

    CAS  PubMed  Google Scholar 

  13. Vrba, R., and Burger, M., Chem. listy, 46, 175 (1952).

    CAS  Google Scholar 

Download references

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FENCL, Z., VINTROVÁ, E. A New Metabolic Regulator : its Stimulation of Citric Acid Production and Anti-sulphon-amide and Streptomycin Effect. Nature 199, 905–906 (1963). https://doi.org/10.1038/199905a0

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