Abstract
EVER since the last century when Alexander Schmidt introduced the idea that the clotting of blood can be due to a fibrin ferment which he named thrombin, efforts have been made to understand how this enzyme arises from prothrombin. He already had the view that lipids are concerned, but never knew about Ac-globulin, which is a plasma constituent important for the generation of thrombin activity in association with lipids.
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References
Seegers, W. H., Levine, W. G., and Shepard, R. S., Canad. J. Biochem. Physiol., 36, 603 (1958).
Kowarzyk, H., and Marciniak, E., Polski Tygodnik Lekarski, 16, 1641 (1961).
Marciniak, E., and Seegers, W. H., Canad. J. Biochem. Physiol., 40, 597 (1962).
Seegers, W. H., Cole, E. R., Harmison, C. R., and Marciniak, E., Canad. J. Biochem. Physiol., 41, 1047 (1963).
Seegers, W. H., Rec. Chem. Prog., 13, 143 (1952).
Seegers, W. H., Cole, E. R., and Marciniak, E., Thromb. Diath. Hœm., 7, 239 (1962).
Cole, E. R., Marciniak, E., and Seegers, W. H., Thromb. Diath. Hœm., 8, 434 (1962).
Ware, A. G., Murphy, R. C., and Seegers, W. H., Science, 106, 618 (1947).
Landaburu, R. H., and Seegers, W. H., Amer. J. Physiol., 193, 169 (1958).
Seegers, W. H., Prothrombin (Harvard Univ. Press, Cambridge, Mass., 1962).
Ware, A. G., and Seegers, W. H., J. Biol. Chem., 172, 699 (1948).
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SEEGERS, W., COLE, E., AOKI, N. et al. Fundamental Function of Ac-globulin and Lipid in Blood Clotting. Nature 200, 1014–1015 (1963). https://doi.org/10.1038/2001014a0
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DOI: https://doi.org/10.1038/2001014a0
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