Abstract
IN view of the high percentage of relapses in cases of brucellosis treated with the antibiotics now in use, we have examined the in vitro effect of synnematin B on Brucella. This antibiotic is unique among the penicillins in that it possesses remarkable activity against a narrow spectrum of Gram-negative organisms. Synnematin B has proved capable of controlling experimental infections in mice caused by Salmonella and Proteus1–3 and natural infections in man4–6. Cultures of mouse fibroblast cells infected with Salmonella typhosa have been freed regularly of infection by treatment with synnematin7. Bacteriostasis of Brucella by 1–2 units/ml. of the antibiotic and bactericidal action against Brucella abortus with 100 units/ml. have been reported8,9. No other reports are known.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Olson, B. H., and Jennings, J. C., Antibiotics and Chemotherapy, 4, 11 (1954).
Rickher, C. J., DeYoung, M., Grundy, W. E., and Sylvester, J. C., Antibiotics Ann., 786 (1956–57).
Hobby, G. L., Pikula-Vrabec, D., Daly, J., Sarroco, G., and Lenert, T. F., Antibiotics Ann., 793 (1956–57).
Benavides, V. L., Olson, B. H., Varela, G., and Holt, S. H., J. Amer. Med. Assoc., 157, 989 (1955).
Henderson, N. D., Garlock, F. C., and Olson, B. H., J. Amer. Med. Assoc., 169, 1991 (1959).
Schwimmer, B., Henderson, N. D., and Olson, B. H., Pub. Health Rep., 76, 630 (1961).
Hopps, H. H., Smadel, J. E., Bernheim, B. C., Danauskas, J. X., and Jackson, E. B., J. Immunol., 87, 162 (1961).
Gottshall, R. Y., Roberts, J. M., Portwood, L. M., and Jennings, J. C., Proc. Soc. Exp. Med., 76, 307 (1951).
Jennings, J. C., and Olson, B. H., Antibiotics and Chemotherapy, 8, 245 (1958).
Richardson, M., and Holt, J. N., J. Bact., 84, 638 (1962).
Dalrymple-Champneys, W., Brucella Infections and Undulant Fever in Man (Oxford Univ. Press, 1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RICHARDSON, M., HOLT, J. Effect of Synnematin B on Brucella. Nature 202, 1010–1012 (1964). https://doi.org/10.1038/2021010b0
Issue Date:
DOI: https://doi.org/10.1038/2021010b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
