Abstract
WHEN a lepidopterous larva such as a cutworm (Noctuidae) in a late stage of infection with a granulosis is shaken up in distilled water, as much as 10 ml. of a fluid of the consistency of thin cream is obtained. This consistency is due to the immense numbers of protein crystals, the granules, each containing a short virus rod, which are liberated from the insect's tissues. Centrifugation of this fluid for 30 min at 5,000 r.p.m. causes the granules to form a sediment and gives a clear supernatant with a greenish opalescence. When this opalescent fluid is examined with the electron microscope it is found to contain large numbers of long virus-like threads branched in an intricate manner.
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References
Smith, Kenneth M., Trontl, Z. M., and Frist, R. H., Virology, 24, 508 (1964).
Hughes, K. M., J. Bact., 64, 375 (1952).
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SMITH, K., BROWN, R. Replication Cycle of an Insect Granulosis Virus. Nature 207, 106–107 (1965). https://doi.org/10.1038/207106a0
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DOI: https://doi.org/10.1038/207106a0
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