Abstract
THE mechanism governing the development and consequences of posthaemorrhagic circulatory collapse has been tentatively related to the activation of the sympathetico-adrenal system. During an early reversible stage after haemorrhage, this activation leads to compensatory readjustments; in a later irreversible stage the persisting sympathetico-adrenal activity brings about vascular and tissue lesions, especially at sites exposed to prolonged vasoconstriction. At this stage the situation cannot be remedied by restoring the blood volume.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rawson, R. A., Chien, S., Peng, M. T., and Dellenback, R. J., Amer. J. Physiol., 196, 179 (1959).
Chien, S., Amer. J. Physiol., 206, 21 (1964).
Wiggers, H. C., Goldberg, H., Roembild, F., and Ingraham, R. C., Circulation, 2, 179 (1950).
Remington, J. W., Hamilton, W. F., Boyd, jun., G. H., Hamilton, jun., W. F., and Caddell, H. H., Amer. J. Physiol., 161, 116 (1950).
Lotz, F., Beck, L., and Stevenson, J. A. F., Canad. J. Biochem. Physiol., 33, 741 (1955).
Zingg, W., Nickerson, M., and Carter, S. A., Surg. Forum, 9, 22 (1958).
Nickerson, M., and Carter, S. A., Canad. J. Biochem., 37, 1161 (1959).
Seifen, E., Flacke, W., and Alper, M. H., Arch. Exp. Path. Pharmak., 248, 27 (1964).
Zaimis, E., Nature, 192, 521 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ANGELUCCI, L., BALDIERI, M. & BUONERBA, M. Increased Tolerance to Posthaemorrhagic Shock in Dogs treated with Reserpine. Nature 214, 202–203 (1967). https://doi.org/10.1038/214202a0
Issue Date:
DOI: https://doi.org/10.1038/214202a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
