Abstract
THE demonstration that increased levels of calcium in cultures of strain L mouse fibroblasts and rat thymocytes stimulated mitosis and reduced, or prevented, the transient mitotic delay produced by irradiation1,2 led to the hypothesis that a rise in the concentration of calcium in the blood and tissues might also stimulate normal mitosis and reduce post-irradiation mitotic delay in the whole animal.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Whitfield, J. F., and Rixon, R. H., Exp. Cell Res., 27, 154 (1962).
Whitfield, J. F., and Youdale, T., Exp. Cell Res., 43, 602 (1966).
Bertalanffy, F. D., and Lau, C., Intern. Rev. Cytol., 13, 357 (1962).
Anderson, N. G., Quart. Rev. Biol., 31, 169, 243 (1956).
St. Amand, G. A., Anderson, N. G., and Gaulden, M. E., Exp. Cell Res., 20, 71 (1960).
Whitfield, J. F., Brohée, H., and Youdale, T., Exp. Cell Res., 36, 341 (1964).
Whitfield, J. F., Brohée, H., and Youdale, T., Publ. EUR 2485. e (European Atomic Energy Community, Brussels, 1965).
Gaulden, M. E., in Mitogenesis (edit. by Ducoff, H. S., and Ehret, C. F.), 35, 43, 44 (The University of Chicago Press, Chicago, 1959).
Rondanelli, E. G., Trenta, A., Magliulo, E., Vannini, V., and Gerna, G., Exp. Cell Res., 41, 1 (1966).
Rixon, R. H., and Whitfield, J. F., Intern. J. Rad. Biol., 3, 361 (1961).
Rixon, R. H., and Whitfield, J. F., Nature, 199, 821 (1963).
Sanfelippo, P. M., Sanfelippo, M. J., and Surak, J. G., Abstract 171, Proc. Thirteenth Ann. Meeting Rad. Res. Soc., Philadelphia, 1965.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PERRIS, A., WHITFIELD, J. Effect of Calcium on Mitosis in the Thymuses of Normal and Irradiated Rats. Nature 214, 302–303 (1967). https://doi.org/10.1038/214302a0
Issue Date:
DOI: https://doi.org/10.1038/214302a0
This article is cited by
-
The regulation of cell proliferation by calcium and cyclic AMP
Molecular and Cellular Biochemistry (1979)
-
Magnesium (and trace substance) deficiencies in the pathogenesis of cancer
Biological Trace Element Research (1979)
-
Calcium, cyclic adenosine 3′, 5′-monophosphate, and the control of cell proliferation: A review
In Vitro (1973)
-
Role of Calcium in the Control of Growth and Cell Division
Nature (1968)
-
Calcium and the Control of Mitosis in the Mammal
Nature (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.