Abstract
RNA tumour viruses are divided on the basis of their biological and serological properties into three major groups: avian leukosis sarcoma, mouse leukaemia sarcoma and mouse mammary tumour1. Common features in electron microscopic appearance2–6, chemical composition7 and the presence of a group-specific antigen common to all members of the respective groups7, suggest that all the viruses may have similar structure. Addition of inhibitors of DNA-dependent RNA synthesis to infected cultures blocks virus production for members of all three groups (refs. 8–10 and unpublished results of R. C. Cardiff and P. B. Blair), so it is also probable that they have some characteristics of replication in common. Single-stranded RNA has been isolated from several of these viruses by the SDS-phenol method11–15. In each case density gradient sedimentation of the RNA yielded a fast-sedimenting component with sedimentation coefficient (Sw) of 60S-75S which was identified as the intact viral UNA, plus a 4S component which was thought to be degraded viral or cellular RNA.
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References
Suggestions for the Classification of Oncogenic RNA Viruses. Contributions from the Stern Symposium on Perspectives in Virology, New York, February 9, 1966. J. Nat. Cancer Inst., 37, 395 (1966).
Vogt, P. K., in Adv. Virus Res. (edit. by Smith, Kenneth M., and Lauffer, Max A.), 11, 293 (Academic Press, New York and London, 1965).
Vogt, P. K., in Nat. Cancer Inst. Monog. (edit. by Beard, Joseph W.), 17, 523 (US Government Printing Office, 1964).
Moloney, J. B., in Ann. Rev. Med. (edit. by Degraff, Arthur), 15, 383 (Annual Reviews, Inc., Palo Alto, 1964).
Bernhard, W., Cancer Res., 20, 712 (1960).
Blair, P. B., in Current Topics in Microbiology and Immunology (in the press, 1968).
Robinson, W. S., and Duesberg, P. H., in Molecular Basis of Virology (edit. by Fraenkel-Conrat, H.), 3B, 306 (Reinhold Publishing Co., New York, 1968).
Temin, H. M., Virology, 20, 577 (1963).
Bader, J. P., Virology, 22, 462 (1964).
Duesberg, P. H., and Robinson, W. S., Virology, 31, 743 (1967).
Robinson, W. S., Pitkanen, A., and Rubin, H., Proc. US Nat. Acad. Sci., 54, 137 (1965).
Galibert, F., Bernard, C., Chenaille, P., and Boiron, M., CR Acad. Sci., 261, 1771 (1965).
Duesberg, P., and Robinson, W. S., Proc. US Nat. Acad. Sci., 55, 219 (1966).
Mora, P. T., McFarland, V. W., and Luborsky, S. W., Proc. US Nat. Acad. Sci., 55, 438 (1966).
Duesberg, P. H., and Blair, P. B., Proc. US Nat. Acad. Sci., 55, 1490 (1966).
Duesberg, P. H., Proc. US Nat. Acad. Sci., 58, 1511 (1968).
Duesberg, P. H., Robinson, H. L., Robinson, W. S., Huebner, R. J., and Turner, H. C., Virology, 36, 73 (1968).
Duesberg, P. H., and Robinson, W. S., Proc. US Nat. Acad Sci., 54, 794 (1965).
Duesberg, P. H., Proc. US Nat. Acad. Sci., 59, 930 (1968).
Spirin, A. S., in Prog. Nucleic Acid Res. (edit. by Davidson, J. N., and Cohn, Waldo E.), 1, 301 (Academic Press, New York and London, 1963).
Martin, R. G., and Ames, B. N., J. Biol. Chem., 236, 1372 (1961).
Duesberg, P. H., and Cardiff, R. C., Virology (in the press).
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BLAIR, C., DUESBERG, P. Structure of Rauscher Mouse Leukaemia Virus RNA. Nature 220, 396–399 (1968). https://doi.org/10.1038/220396a0
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DOI: https://doi.org/10.1038/220396a0
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