Abstract
Engel and Forbes1,2 noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen3 proposed that this syndrome is probably associated with dizygotic twinning. He also summarized the results of three surveys which indicate that the frequency of twin births in sibships containing Turner's syndrome is about twice that in the general population. He concluded3 that similar mechanisms may be responsible for sex chromosome non-disjunction and dizygotic twinning.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Engel, E., and Forbes, A. P., Harper Hosp. Bull., 21, 83 (1963).
Engel, E., Lancet, i, 1271 (1967).
Nielsen, J., J. Med. Genet., 3, 77 (1966).
Registrar General's Statistical Review of England and Wales for the Year 1956, Part III (HMSO, London, 1958).
Eriksson, A. W., and Fellman, J., Acta Genet. Basel, 17, 385 (1967).
Shipley, P. W., Wray, J. A., Hechter, H. H., Arellano, M. G., and Borhani, N. O., Amer. J. Epidemiol., 85, 147 (1967).
Mackay, I. R., and Burnet, F. M., Autoimmune Disease (Thomas, Springfield, Illinois, 1963).
Burch, P. R. J., An Inquiry Concerning Growth, Disease and Ageing (Oliver and Boyd, Edinburgh, 1968).
Nielsen, J., Lancet, i, 1376 (1966).
Menzinger, G., Fallucca, F., and Andreani, D., Lancet, ii, 747 (1966).
Wais, S., and Salvati, E., Lancet, ii, 747 (1966).
Zuppinger, K., Engel, E., Forbes, A. P., Mantooth, L., and Claffey, J., Acta Endocrinol., Suppl. 113, 54, 5 (1967).
Spiegelman, M., and Marks, H. H., Amer. J. Publ. Health, 36, 26 (1946).
Burch, P. R. J., Rowell, N. R., and Burwell, R. G., Lancet, ii, 170 and 748 (1966).
Nielsen, J., Lancet, ii, 748 (1966).
Vallotton, M. B., and Forbes, A. P., Lancet, i, 648 (1967).
Burch, P. R. J., and Burwell, R. G., Quart. Rev. Biol., 40, 252 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BURCH, P. Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus. Nature 221, 175–177 (1969). https://doi.org/10.1038/221175a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/221175a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
