Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Partial Inhibition by Mepacrine of the Development of Sulphonamide Resistance in Plasmodium berghei

Nature volume 223, pages 858–859 (1969)Cite this article

Abstract

RECENTLY interest has revived in the activity of the sulphonamides and sulphones against strains of malaria parasites, especially P. falciparum, that are resistant to other drugs such as chloroquine and pyrimethamiiie1. A number of acridine derivatives, including mepacrine, prevent the emergence in vitro of resistance to sulphonamides and certain antibiotics in Staphylococcus spp.2,3. Because mepacrine itself is a potential antimalarial blood schizontocide it seemed of interest to explore whether the simultaneous administration of mepacrine and a sulphonamide in malaria would result in any change in the pattern of development of resistance of the parasites to either drug.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. WHO Tech. Rep. Ser., No. 375 (1967).

  2. Sevag, M. G., Arch. Biochem. Biophys., 108, 85 (1964).

    Article  CAS  Google Scholar 

  3. Sevag, M. G., and Ashton, B., Nature, 203, 1323 (1964).

    Article  ADS  CAS  Google Scholar 

  4. Peters, W., Exp. Parasit., 17, 80 (1965).

    Article  CAS  Google Scholar 

  5. Bishop, A., and McConnachie, E. W., Nature, 162, 541 (1948).

    Article  ADS  CAS  Google Scholar 

  6. Bishop, A., and McConnachie, E. W., Parasitology, 40, 163 (1950).

    Article  CAS  Google Scholar 

  7. Ramakrishnan, S. P., Prakash, S., Choudhury, D. S., and Basu, P. C., Indian J. Malar., 15, 95 (1961).

    CAS  Google Scholar 

  8. Peters, W., Nature, 208, 693 (1965).

    Article  ADS  CAS  Google Scholar 

  9. Arai, T., and Watanabe, T., Genet. Res., 10, 241 (1967).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool

    W. PETERS

Authors
  1. W. PETERS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PETERS, W. Partial Inhibition by Mepacrine of the Development of Sulphonamide Resistance in Plasmodium berghei. Nature 223, 858–859 (1969). https://doi.org/10.1038/223858b0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/223858b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing