Abstract
THE immune response can be inhibited by passive administration of specific antibody1. It is generally assumed that the antibody, presumably by covering the antigenic determinants of the antigen, prevents the interaction of antigen with the receptors on the target cells. The immune response to sheep red blood cells (SRC) can be studied in vitro with Mishell and Dutton's2 technique. We have investigated the conditions of antibody inhibition of this in vitro response to understand better the role of antigen in antibody stimulation.
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References
Uhr, J. W., and Möller, G., Advanc. Immunol., 8, 81 (1968).
Mishell, R. J., and Dutton, R. W., J. Exp. Med., 126, 423 (1967).
Kabat, E. A., and Mayer, M. M., Experimental Immunochemistry (C. C. Thomas, Springfield, 1961).
Möller, G., and Wigzell, H., J. Exp. Med., 121, 969 (1965).
Henry, C., and Jerne, N. K., J. Exp. Med., 128, 133 (1968).
Mosier, D. E., J. Exp. Med., 129, 351 (1969).
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LANG, W., NASE, S. & RAJEWSKY, K. Inhibition of the Immune response in vitro to Sheep Red Blood Cells by Passive Antibody. Nature 223, 949–950 (1969). https://doi.org/10.1038/223949a0
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DOI: https://doi.org/10.1038/223949a0
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