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Detection of Inactive Enzyme Molecules in Ageing Organisms

Abstract

Using immunochemical techniques, evidence is obtained that older nematodes (Turbatrix aceti) contain two populations of enzyme molecules—one active and the other totally inactive.

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References

  1. Yanofsky, C., and Stadler, J., Proc. US Nat. Acad. Sci., 44, 245 (1958).

    Article  ADS  CAS  Google Scholar 

  2. Gershon, D., Exp. Gerontol. (in the press).

  3. Pai, S., Z. Wiss. Zool., 131, 293 (1928).

    Google Scholar 

  4. Rothstein, M., and Cook, E., Comp. Biochem. Physiol., 17, 638 (1966).

    Google Scholar 

  5. Erlanger, M., and Gershon, D., Exp. Gerontol. (in the press).

  6. Rothstein, M., and Mayoh, H., Comp. Biochem. Physiol., 16, 361 (1965).

    Article  CAS  PubMed  Google Scholar 

  7. John, P. C. L., and Syrett, P. J., Biochem. J., 105, 409 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Shiio, I., Shiio, T., and McFadden, B. A., Biochim. Biophys. Acta, 96, 114 (1965).

    Article  CAS  PubMed  Google Scholar 

  9. Dixon, M., and Kornberg, H. L., Biochem. J., 72, 3P (1955).

    Google Scholar 

  10. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

  11. Kabat, E. A., and Mayer, M. M., Experimental Immunochemistry, second ed., chap. 2 (Thomas, Springfield, 1961).

    Google Scholar 

  12. Cinader, B., in Antibodies to Biologically Active Molecules (edit. by Cinader. B.), 85 (Pergamon, London, 1967).

    Google Scholar 

  13. Orgel, L. E., Proc. US Nat. Acad. Sci., 49, 517 (1963).

    Article  ADS  CAS  Google Scholar 

  14. Palmer, W. G., and Papaconstantinou, J., Proc. US Nat. Acad. Sci., 64, 404 (1969).

    Article  ADS  CAS  Google Scholar 

Download references

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GERSHON, H., GERSHON, D. Detection of Inactive Enzyme Molecules in Ageing Organisms. Nature 227, 1214–1217 (1970). https://doi.org/10.1038/2271214a0

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  • DOI: https://doi.org/10.1038/2271214a0

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