Abstract
The nucleophosmin (NPM) gene is involved in two recurrent translocations in hematological malignancies: t(2;5) (p23;q35) in anaplastic large cell lymphoma (ALCL) and t(3;5)(q25.1;q34–35) in myelodysplasia and acute non-lymphocytic leukemia (ANLL). Using eight YACs encompassing the 5q34-q35 region, we could easily detect these two translocations. In both types of translocation, probable unexpected deletions were also discovered downstream of the breakpoint at 5q35.
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Dragon-Durey, MA., Goguel, AF., Leonard, C. et al. Non-Hodgkin’s lymphomas and myeloid disorders: deletions associated with t(2;5) and t(3;5) detected by FISH. Leukemia 12, 1159–1162 (1998). https://doi.org/10.1038/sj.leu.2401047
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DOI: https://doi.org/10.1038/sj.leu.2401047