This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Constitutive AKT activation in follicular lymphoma
BMC Cancer Open Access 05 August 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Accession codes
References
Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M . Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 2003; 102: 972–980.
Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD . Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci 1997; 22: 267–272.
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ et al. P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci USA 1997; 94: 4330–4335.
Sujobert P, Bardet V, Cornillet-Lefebvre P, Hayflick JS, Prie N, Verdier F et al. Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood 2005; 106: 1063–1066.
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004; 304: 554.
Samuels Y, Diaz Jr LA, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 2005; 7: 561–573.
Kang S, Bader AG, Vogt PK . Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA 2005; 102: 802–807.
Zheng R, Levis M, Piloto O, Brown P, Baldwin BR, Gorin NC et al. FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Blood 2004; 103: 267–274.
Ozeki K, Kiyoi H, Hirose Y, Iwai M, Ninomiya M, Kodera Y et al. Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia. Blood 2004; 103: 1901–1908.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cornillet-Lefebvre, P., Cuccuini, W., Bardet, V. et al. Constitutive phosphoinositide 3-kinase activation in acute myeloid leukemia is not due to p110δ mutations. Leukemia 20, 374–376 (2006). https://doi.org/10.1038/sj.leu.2404054
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2404054
This article is cited by
-
Constitutive AKT activation in follicular lymphoma
BMC Cancer (2014)
-
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner
Oncogene (2014)
-
Expression of different functional isoforms in haematopoiesis
International Journal of Hematology (2014)
-
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway
Leukemia (2011)
-
The emerging mechanisms of isoform-specific PI3K signalling
Nature Reviews Molecular Cell Biology (2010)