Table 2 Response after GO treatment

From: High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: a prospective study of the alfa group

Early deaths

4/57 (7%)

 

Blast clearance at day 15

25/46 (54%)

 

Therapeutic failures

36/57 (63.1%)

 

ORR after GO

19/57 (33.3%)

 

CR

15/57 (26%)

 

CRp

4/57 (7%)

 

ORR by cytogenetic risk groups

 Intermediate

15/43 (35%)

P=0.25

 Poor

3/12 (25%)

 

ORR by age (years)

  

 Age >60

14/35 (40%)

P=0.73

 Age <60

5/22 (22.7%)

 

ORR by duration of first remission (months)

 <12

8/32

P=0.16

 >12

11/25

 

Pgp function

 CR+CRp

0.10±0.09

P=0.0001

 NR

0.37±0.21

 

MRP1 function

 CR+CRp

0.15±0.14

P=0.004

 NR

0.35±0.20

 
  1. Abbreviations: CR, complete remission; CRp, complete remission with incomplete platelet recovery; GO, gemtuzumab ozogamicin; ORR, overall response rate (CR+CRp); Pgp, P-glycoprotein.
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