Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

MicroRNA losses in the frequently deleted region of 7q in SMZL

Leukemia volume 21, pages 2547–2549 (2007)Cite this article

Splenic marginal zone lymphoma (SMZL) is a recently described B-cell malignancy whose molecular pathogenesis requires further investigation. In contrast with other small B-cell lymphomas, SMZL lacks balanced chromosomal translocations that deregulate the expression of oncogenes like BCL2, CCND1, BCL6 and others. In contrast, around 45% of SMZL cases harbor 7q32 deletions, a chromosomal loss that seems to be quite specific to this particular condition.1 Different expression-profiling studies have identified a set of genes that are potentially involved in SMZL pathogenesis, such as TCL1A, AKT1 and others belonging to the BCR downstream signaling and NF-kB activation pathway.2, 3 Nevertheless, the precise mechanism and role of these genes and pathways have not been fully clarified.

The most distinctive molecular alteration identified in SMZL seems to be the loss of the 7q32 region, which, in some cases, occurs in both alleles. The presence of this recurrent abnormality suggests that this region may contain a novel, and as yet unidentified, tumor-suppressor gene. The minimal common deleted region (CDR) in 7q is confined to 7q32.4 Strikingly, this area contains a high density of microRNAs (miRNAs), which are gene expression regulators that not only have been described as being involved in crucial biological processes, including development, differentiation, apoptosis and proliferation control, but also have been proposed as contributing to oncogenesis, either as tumor suppressors or as oncogenes (reviewed by Calin and Croce5).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Mateo M, Mollejo M, Villuendas R, Algara P, Sanchez-Beato M, Martinez P et al. 7q31-32 allelic loss is a frequent finding in splenic marginal zone lymphoma. Am J Pathol 1999; 154: 1583–1589.

    Article  CAS  Google Scholar 

  2. Ruiz-Ballesteros E, Mollejo M, Rodriguez A, Camacho FI, Algara P, Martinez N et al. Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis. Blood 2005; 106: 1831–1838.

    Article  CAS  Google Scholar 

  3. Thieblemont C, Nasser V, Felman P, Leroy K, Gazzo S, Callet-Bauchu E et al. Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis. Blood 2004; 103: 2727–2737.

    Article  CAS  Google Scholar 

  4. Gruszka-Westwood AM, Hamoudi R, Osborne L, Matutes E, Catovsky D . Deletion mapping on the long arm of chromosome 7 in splenic lymphoma with villous lymphocytes. Gene Chromosome Cancer 2003; 36: 57–69.

    Article  CAS  Google Scholar 

  5. Calin GA, Croce CM . MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857–866.

    Article  CAS  Google Scholar 

  6. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005; 353: 1793–1801.

    Article  CAS  Google Scholar 

  7. Yu J, Wang F, Yang GH, Wang FL, Ma YN, Du ZW et al. Human microRNA clusters: genomic organization and expression profile in leukemia cell lines. Biochem Biophys Res Commun 2006; 349: 59–68.

    Article  CAS  Google Scholar 

  8. Pekarsky Y, Santanam U, Cimmino A, Palamarchuk A, Efanov A, Maximov V et al. Tcl1 Expression in Chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res 2006; 66: 11590–11593.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank the skilled assistance of Lydia Sanchez (CNIO) with the immunohistochemical studies, and Yolanda Vicente (HVS) (CAO6/0006) for their excellent technical support. This work was partially supported by grants from the Ministerio de Ciencia y Tecnología (SAF2004-04286, SAF2005-00221), Fundación La Caixa, Ministerio de Sanidad y Consumo (FIS PI052621, FIS PI051623, INT06/062), Servicio de Salud de Castilla la Mancha (SESCAM #06047-00), and Consejería de Sanidad de la Junta de Comunidades de Castilla-La Mancha (#02031), Spain.

Author information

Authors and Affiliations

  1. Department of Genetics and Pathology, Hospital Virgen de la Salud (HVS), Toledo, Spain

    E Ruiz-Ballesteros, M Mollejo, M Mateo, P Algara & P Martínez

  2. Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas (CNIO), Madrid, Spain

    M A Piris

Authors
  1. E Ruiz-Ballesteros
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Mollejo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M Mateo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P Algara
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P Martínez
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M A Piris
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E Ruiz-Ballesteros.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ruiz-Ballesteros, E., Mollejo, M., Mateo, M. et al. MicroRNA losses in the frequently deleted region of 7q in SMZL. Leukemia 21, 2547–2549 (2007). https://doi.org/10.1038/sj.leu.2404853

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404853

This article is cited by

Search

Advanced search

Quick links