Abstract
INTERFERON has been reported to play an important role in immune responses1–6. Using interferon3,5,6 acceleration of mouse skin allograft rejection has been demonstrated in addition to an increase in the cytotoxic action of lymphocytes on appropriate target cells in vitro. It has also been shown that prolongation of skin allografts can be achieved by the use of anti-interferon serum3. To further test the possibility of involvement of interferon in immune responses an attempt is here described to block the interferon effect by anti-interferon serum.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Green, J. A., Cooperband, S. R., and Kibrick, S., Science, N.Y., 164, 1415 (1969).
Green, J. A., Cooperband, S. R., Lourence, F. R., and Kibrick, S., Ann. N.Y. Acad. Sci., 173, 736 (1970).
Skurkovich, S. V., Klinova, E. G., Alexandrovskaya, I. M., Levina, N. V., Arkhipova, N. A., and Bulycheva, T. I., Proc. Thirteenth I.S.B.T. Cong., Washington (1972).
Skurkovich, S. V., and Alexandrovskaya, I. M., Probl. Gematol. (in Russian), 3, 34 (1973).
Skurkovich, S. V., Klinova, E. G., Alexandrovskaya, I. M., Levina, N. V., Arkhipova, N. A., and Bulycheva, T. I., Bull. exp. Biol. (in Russian), 4, 66 (1973).
Skurkovich, S. V., Klinova, E. G., Alexandrovskaya, I. M., Levina, N. V., Arkhipova, N. A., and Bulycheva, T. I., Immunology, 25, 317 (1973).
Terasaki, P. I., and McClelland, J. D., Nature, 204, 998 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SKURKOVICH, S., KLINOVA, E., EREMKINA, E. et al. Immunosuppressive Effect of an Anti-interferon Serum. Nature 247, 551–552 (1974). https://doi.org/10.1038/247551a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/247551a0
This article is cited by
-
Preparation of monospecific immunoglobulin against human leukocytic interferon
Bulletin of Experimental Biology and Medicine (1978)
-
Increase in sensitivity of leukemic cells incubated in interferon to the action of immune serum
Bulletin of Experimental Biology and Medicine (1976)
-
Enhancement of the immune response by immunization with L1210 cells preincubated in interferon
Bulletin of Experimental Biology and Medicine (1976)
-
Increased cellular immune response during immunization of mice with cells preincubated in interferon
Bulletin of Experimental Biology and Medicine (1976)
-
Stimulation of humoral immunity to surface antigens of leukemic cells by interferon-containing serum
Bulletin of Experimental Biology and Medicine (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.