Abstract
THE major histocompatibility (H) antigens of higher animals show extreme genetic polymorphism equalled, in higher vertebrates, only by that associated with the immunoglobulins1. Maintenance of such a high rate of variability implies evolutionary advantage for heterozygotes in the HL-A system for man, or at the H-2 gene complex in mice2,3. We propose a possible selective mechanism, based on the realisation that immunological surveillance function (defined here as recognition and elimination of modified host cells by sensitised thymus-derived lymphocytes (T-cells) may be considerably enhanced in mice heterozygous at the H-2 gene complex.
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References
Amos, D. B. et al., Fedn Proc., 31, 1087–1104 (1972).
Bodmer, W. F., Nature, 237, 139–145 (1972).
Burnet, F. M., Nature, 245, 359–361 (1973).
Zinkernagel, R. M., and Doherty, P. C., J. exp. Med., 138, 1266–1269 (1973); Nature, 248, 701–702; 251, 547–548 (1974); J. exp. Med. (in the press).
Doherty, P. C., and Zinkernagel, R. M., Transplant. Rev., 19, 89–120 (1974); J. Immun., 114, 30–33 (1975); J. exp. Med., 141, 502–507 (1975).
Gardner, I., Bowern, N. A., and Blanden, R. V., Eur. J. Immun. (in the press).
Blanden, R. V. et al., Nature, 254, 269–270 (1975).
Cerottini, J. -C., and Brunner, K. T., Adv. Immun., 19, 67–132 (1974).
Mims, C. A., and Blanden, R. V., Infect. Immun., 6, 695–698 (1972).
Blanden, R. V., Transplant. Rev., 19, 56–88 (1974).
Cole, G. A., Nathanson, N., and Prendergast, R. A., Nature, 238, 335–337 (1972).
Hotchin, J., Mongr. Virol., 3, 1–211 (1971).
Doherty, P. C., Zinkernagel, R. M., and Ramshaw, I. A., J. Immun., 112, 1548–1552 (1974).
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DOHERTY, P., ZINKERNAGEL, R. Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex. Nature 256, 50–52 (1975). https://doi.org/10.1038/256050a0
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DOI: https://doi.org/10.1038/256050a0
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