Abstract
THE neoplasm mKSA, an SV40-induced sarcoma in BALB/c strain mice has strong, SV40-specific tumour rejection antigens (TSTA). This parental line is also very oncogenic with a tumour dose 50 (TD50) of 102 cells. A subline, passaged in monolayer tissue culture (mKSA-TC), has a much reduced tumour-inducing capacity (TD50 = 2 × 106–2 × 107, cells). Of these mKSA-TC cells 1 × 105 will immunise syngeneic hosts against a challenge of 1 × 106 mKSA cells carried in an ascitic form (mKSA-ASC); immunisation against other SV40-induced BALB/c sarcomas (for example, SVA31C14 and E4) has also been achieved, but not against Adj-PC-5 (ref. 1) nor against Meth A (ref. 2), both neoplasms carrying specific TSTAs and syngeneic with BALB/c but induced by chemical carcinogens.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Potter, M., and Walters, J. L., J. natn. Cancer Inst., 51, 875 (1973).
McCollester, P. L., Cancer Res., 30, 2382 (1970).
Strober, S., Appella, E., and Law, L. W., Proc. natn. Acad. Sci. U.S.A., 67, 765 (1970).
Law, L. W., Appella, E., Strober, S., Wright, P. W., and Fischetti, T., Transplantation, 18, 487 (1974).
Drapkin, M. S., Appella, E., and Law, L. W., J. natn. Cancer Inst., 52, 259 (1974).
Law, L. W., and Appella, E., Nature, 243, 83 (1973).
Chang, K. S. S., Law, L. W., and Appella, E., Int. J. Cancer, 15, 483 (1975).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265 (1951).
Dean, J. H., McCoy, J. L., Lewis, D., Appella, E., and Law, L. W., Int. J. Cancer (in the press).
Howell, S. B., Dean, J. H., and Law, L. W., Int. J. Cancer, 15, 152 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LAW, L., HENRIKSEN, O. & APPELLA, E. Tumour rejection properties of solubilised TSTA from an SV40-induced neoplasm. Nature 257, 234–235 (1975). https://doi.org/10.1038/257234a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/257234a0
This article is cited by
-
T–T cell collaboration in rejection of a syngeneic SV40-induced sarcoma in mice
Nature (1978)
-
Tumour-specific transplantation antigen from SV40 transformed cells binds to DNA
Nature (1977)
-
H–2-like specificities of foreign haplotypes appearing on a mouse sarcoma after vaccinia virus infection
Nature (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
