Abstract
STUDIES in mechanisms of T–B collaboration in the immune response have shown that T cells can produce factors after stimulation with antigen1–3, allogeneic cells4–6, or mitogens (ref. 7 and O. Sjöberg, unpublished), that can stimulate B cell responses to antigens. Such factors have been categorised as specific1,3 or nonspecific (refs 4–7 and O. Sjöberg, unpublished). Studies have shown that the specific factor produced by (T,G–A—L) stimulation of educated T cells8 is able to promote antibody formation by both syngeneic and allogeneic cells. Similarly, with one exception6, nonspecific factors from antigen- or mitogen-activated T cells were able to cooperate with B cells from histoincompatible strains7,9. Reports that histoincompatible T and B cells could not be demonstrated to cooperate in a humoral immune response10, in conditions in which it was consided that inhibitory allogeneic effects were excluded or irrelevant, indicated that for efficient collaboration T and B cells need to share surface determinants coded for by major histocompatibility complex (MHC), in particular the I region or its equivalent. One report11 argued against this;allophenic mice (C3H + C57BL) were able to make non-responder allotype towards (T,G)–A—L. This finding made the presumption that it was the high responder T cells which were collaborating with the low responder B cells, but could not exclude that alternative cooperative mechanisms were operational.
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WALDMANN, H., POPE, H. & MUNRO, A. Cooperation across the histocompatibility barrier. Nature 258, 728–730 (1975). https://doi.org/10.1038/258728a0
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DOI: https://doi.org/10.1038/258728a0
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