Abstract
OESTROGEN-SENSITIVE cells contain cytoplasmic macro-molecules called receptors1,2. They bind oestrogen to form complexes which are translocated to the nucleus where they may bind to specific acceptor sites3–5. This interaction of receptor–hormone complex with nuclear acceptor sites is assumed to be responsible for the stimulation of RNA, DNA and protein synthesis that results in growth of the tissue3–5. The demonstration of nuclear acceptor sites has been difficult and controversial6,7. We present here evidence that a limited number of receptor–oestrogen complexes are bound in the nucleus of rat uterine cells and that these sites may be specific nuclear acceptor sites.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gorski, J., Toft, D., Shyamala, G., Smith, D., and Notides, A., Rec. Prog. Hormone Res., 24, 45–80 (1968).
Jensen, E. V., and DeSombre, E. R., A. Rev. Biochem., 41, 203–230 (1972).
O'Malley, B. W., and Means, A. R., Science, 183, 610–620 (1974).
Anderson, J. N., Peck, E. J., Jr, and Clark, J. H., Endocrinology, 92, 1488–1495 (1973).
Clark, J. H., Anderson, J. N., and Peck, E. J., Jr, in Receptors for Reproductive Hormones, 36 (edit. by O'Malley, B. W., and Means, A. R.), 15–59 (Plenum, New York, 1973).
Chamness, G. C., Jennings, A. W., and McGuire, W. L., Biochemistry, 13, 327–331 (1974).
Buller, R. E., Schrader, W. T., and O'Malley, B. W., J. biol. Chem., 250, 809–818 (1975).
Alberga, A., Massol, N., Raynaud, J. P., and Baulieu, E. E., Biochemistry, 10, 3835 (1971).
Fang, S., and Liao, S., J. biol. Chem., 246, 16–24 (1971).
Mainwaring, W. I. P., and Peterken, B. M., Biochem. J., 125, 285–295 (1971).
King, R. J. B., and Gordon, J., Nature new Biol., 240, 185–187 (1972).
O'Malley, B. W., Spelsberg, T. C., Schrader, W. T., Chytil, F., and Steggles, A. W., Nature, 235, 141–144 (1972).
Higgins, S. J., Rousseau, G. G., Baxter, J. D., and Tomkins, G. M., J. biol. Chem., 248, 5873–5879 (1973).
Kalimi, M., Beato, M., and Feigelson, P., Biochemistry, 12, 3365–3371 (1973).
Chamness, G. C., Jennings, A. W., and McGuire, W. L., Nature, 241, 458–460 (1973).
Audre, J., and Rochefort, H., FEBS Lett., 50, 319–323 (1975).
Yamamoto, K. R., and Alberts, B., Cell, 4, 301–310 (1975).
Clark, J. H., and Gorski, J., Biochim. biophys. Acta, 192, 508–515 (1969).
Anderson, J. N., Clark, J. H., and Peck, E. J., Jr, Biochem. biophys. Res. Commun., 48, 1460–1468 (1972).
Anderson, J. N., Peck, E. J., Jr, and Clark, J. H., Endocrinology, 96, 160–167 (1975).
Clark, J. H., Peck, E. J., Jr, Schrader, W. T., and O'Malley, B. W., in Methods in Cancer Research (edit. by Busch and Harris (Academic, in the press).
Puca, G. A., and Brecni, F., Nature, 218, 967–969 (1968).
DeHertogh, R., Ekka, E., Vanderheyden, J., and Hoet, J. J., J. Steroid Biochem., 4, 313–320 1973).
Mester, J., and Baulieu, E. E., Biochem. J., 146, 617 (1975).
Anderson, J., Clark, J. H., and Peck, E. J., Jr, Biochem. J., 126, 561 (1972).
Sala-Trepat, J. M., and Reti, E., Biochim. biophys. Acta, 338, 92–103 (1974).
Jaffe, R. C., Socher, S. H., and O'Malley, B. W., Biochim. biophys. Acta, 399, 403–419 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CLARK, J., PECK, E. Nuclear retention of receptor–oestrogen complex and nuclear acceptor sites. Nature 260, 635–637 (1976). https://doi.org/10.1038/260635a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/260635a0
This article is cited by
-
Transdermal estradiol for postpartum depression: results from a pilot randomized, double-blind, placebo-controlled study
Archives of Women's Mental Health (2020)
-
Femara® and the future: tailoring treatment and combination therapies with Femara
Breast Cancer Research and Treatment (2007)
-
The effect of homogenization temperature upon the apparent cellular compartmentalization of unoccupied estrogen receptor
Experientia (1989)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.