Abstract
CHOLESTEROL, almost water insoluble, normally occurs in the body bound to lipoprotein, or incorporated in lipid aggregations such as bile micelles, or within certain biomembranes. When cholesterol levels are abnormally high, single crystals of the monohydrate tend to deposit; in bile, clumps of these crystals form gallstones1. Crystals of cholesterol monohydrate also occur in atherosclerotic lesions2. Earlier reports of crystal data for cholesterol monohydrate are not all consistent, although they indicate a structure of unusual complexity (refs 1, 3–5 and S. H. Kim and W. Warrant, personal communication). The crystal structure (Fig. 1)has now been determined by a molecular replacement method which was developed primarily for protein crystallography6.
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References
Bogren, H., and Larsson, K., Biochim. biophys. Acta, 75, 65–69 (1963).
Small, D. M., and Shipley, G. G., Science, 185, 222–229 (1974).
Bernal, J. D., Crowfoot, D., and Fankuchen, I., Proc. R. Soc., A 239, 135–182 (1940).
Klotzer, F., Zeit. Krystallogr., 95, 338–367 (1936).
Tazaki, H., Tatibana, N., and Tatibana, I., J. Sci. Hiroshima. Univ., ser. AII, 103 (1941).
Crowther, R. A., in The Molecular Replacement Method, (edit. by Rossman, M. G. ), 171–177 (Gordon and Breach, New York, 1973).
Craven, B. M., ROTRAN Computer Programs (Technical Report, Crystallography Department, University of Pittsburgh, 1975).
Craven, B. M., and De Titta, G. T., J. chem. Soc. (in the press).
Pimental, G. C., and McClellan, A. L., The Hydrogen Bond (Freeman, San Francisco, 1960).
Lonsdale, K., Nature, 217, 56–58 (1968).
Kay, M. I. Young, R. A., and Posner, A. S., Nature, 204, 1050–1052 (1964).
Spector, M., Krokowsky, E. M., Sax, M., and Pletcher, J., Science, 165, 711 (1969).
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CRAVEN, B. Crystal structure of cholesterol monohydrate. Nature 260, 727–729 (1976). https://doi.org/10.1038/260727a0
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DOI: https://doi.org/10.1038/260727a0
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