Abstract
Sodium channels in nerve membranes are postulated to be surrounded by lipid molecules in the gel (or crystalline) phase. Addition of local anaesthetics triggers a change in the surrounding lipids to the fluid, liquid crystalline phase, allowing the sodium channel to close with resulting local anaesthesia. The experimental evidence for this model is discussed.
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Lee, A. Model for action of local anaesthetics. Nature 262, 545–548 (1976). https://doi.org/10.1038/262545a0
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DOI: https://doi.org/10.1038/262545a0
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