Abstract
IT has been generally concluded that the inherent programme of sexual differentiation in both sexes of mammals is female. If androgens are present during the critical periods of sexual differentiation, then both genetic males and females will be organised for masculine reproductive organs1, hepatic steroidogenic enzymes2, hypothalamic control of gonadotropin secretion (tonic)3 and sexual behaviour4; whereas an absence of either gonad during the critical developmental periods allows for the expression of the inborn female programme1–3,5. These results have led to the generally held concept that feminine differentiation requires no hormonal imprinting and will occur normally as long as androgens are not present during the critical periods of sexual embryogenesis. We have reported, however, that interference with perinatal pituitary or adrenal function in female rats causes defects in normal pubertal feminine development which suggests that endogenous hormones may be essential for feminine organisation6. Unlike oestradiol and testosterone which both masculinise the female rat7, progesterone treatment antagonises these effects and protects the developing female from exogenous oestrogens and androgens8. In fact, serum progesterone levels in the foetal monkey have been shown to be significantly higher in the female than in the male9 and we have recently postulated that perinatal progesterone may be required for feminine neural differentiation10. We present here evidence demonstrating that neonatal female rats have a markedly higher level of serum and adrenal progesterone than do neonatal males, and since serum progesterone levels can be further increased by exogenous gonadotropins–adrenal (progesterone) axis may be required for normal feminine sexual differentiation.
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References
Jost, A., Rec. Prog. Horm. Res., 8, 379–413 (1953).
DeMoor, P., and Denef, C., Endocrinology, 82, 480–492 (1968).
Pfeiffer, C. A., Am. J. Anat., 58, 195–225 (1936).
Grady, K. L., Phoenix, C. H., and Young, W. C., J. comp. physiol. Psychol., 59, 176–182 (1965).
Steinbeck, H., and Neumann, F., in Psychopharmacology, Sexual Disorders and Drug Abuse (edit. by Ban, T. A., et al.), 503–516 (North Holland, Amsterdam, 1973).
Shapiro, B. H., Goldman, A. S., and Root, A. W., Proc. Soc. exp. Biol. Med., 145, 334–339 (1974).
Barraclough, C. A., and Turgeon, J. L., Symp. Soc. dev. Biol., 33, 255–273 (1975).
Dorfman, R. I., Anat. Rec., 157, 547–558 (1967).
Hagemenas, F. C., and Kittenger, G. W., Endocrinology, 91, 253–256 (1972).
Shapiro, B. H., Goldman, A. S., Steinbeck, H. F., and Neumann, F., Experientia, 32, 650–651 (1976).
Schmidt-Elmendorff, H., Loraine, J. A., and Bell, E. T., J. Endocrinol., 24, 349–357 (1962).
Resko, J. A., Science, 164, 70–72 (1969).
Piva, F., Gagliano, P., Motta, M., and Martini, L., Endocrinology, 93, 1178–1184 (1973).
Schlegel, R. J., Farias, E., Russo, N. C., Moore, J. A., and Gardner, L. I., Endocrinology, 81, 565–572 (1967).
Weisz, J., and Gunsalus, P., Endocrinology, 93, 1057–1065 (1973).
Price, D., and Ortiz, E., Endocrinology, 34, 215–239 (1944).
Goldenberg, R. L., Reiter, E. O., and Ross, G. T., Fert. Steril., 24, 121–125 (1973).
Araki, S., Toran-Allerand, C. D., Ferin, M., and Vande Wiele, R. L., Endocrinology, 97, 693–697 (1975).
Root, A. W., Shapiro, B. H., Duckett, G. E., and Goldman, A. S., Proc. Soc. exp. Biol. Med., 148, 631–633 (1975).
Goldman, B. D., Grazia, Y. R., Kamberi, I. A., and Porter, J. C., Endocrinology, 88, 771–776 (1971).
Dohler, K. D., and Wuttke, W., Endocrinology, 97, 898–907 (1975).
Abraham, G. E., Swerdloff, R., Tulchinsky, D., and Odell, W. D., J. clin. Endocr. Metab., 32, 619–624 (1971).
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SHAPIRO, B., GOLDMAN, A., BONGIOVANNI, A. et al. Neonatal progesterone and feminine sexual development. Nature 264, 795–796 (1976). https://doi.org/10.1038/264795a0
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DOI: https://doi.org/10.1038/264795a0
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