Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Immunologic studies in contacts of osteosarcoma in humans and animals

Nature volume 265, pages 541–542 (1977)Cite this article

Abstract

AGENT(S) which could cause unrecognised or subclinical infections in otherwise healthy human household contacts of cancer patients may he detected by epidemiologic studies. Support for this hypothesis is provided by the reports of an increase in tumour specific humoral antibodies, as well as tumour specific cell mediated immunity1–4 in the household contacts of patients with osteosarcoma, adenocarcinoma of the breast and other malignancies. Clear evidence for the validity of this conclusion has not been obtained. To test this hypothesis, we studied antibodies (both humoral and cellular) in the household contacts of a patient with osteosarcoma. In addition, in an animal model for human osteosarcoma, we characterised the sera and lymphocytes of hamster mothers (in close contact with their offspring) before and after induction of the tumour in their immunosuppressed offspring.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Morton, D. L. & Malgren, R. A. Science 162, 1279–1281 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Priori, E. S., Wilbur, J. R. & Dmochowski, J. natn. Cancer Inst. 46, 1299–1308 (1971).

    CAS  Google Scholar 

  3. Hellström, L., Hellström, K. E., Bill, A. H., Pierce, G. E. & Yang, J. P. S. Int. J. Cancer 6, 172–188 (1970).

    Article  PubMed  Google Scholar 

  4. Byers, V. S., Levin, A. S., Hackett, A. J. & Fundenberg, H. H. J. clin. Invest. 58, 500–513 (1975).

    Article  Google Scholar 

  5. Singh, I., Tsang, K. Y. & Blakemore, W. S. J. natn. Cancer Inst. 58 (in the press).

  6. Morton, D. L., Malgren, R. A., Hall, W. T. & Schidlowsky, G. Surgery 66, 152–161 (1969).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Orthopaedics, Department of Surgery, Medical College of Ohio, P.O. Box 6190, Toledo, Ohio, 43614

    IQBAL SINGH, KWONG Y. TSANG & WILLIAM S. BLAKEMORE

Authors
  1. IQBAL SINGH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. KWONG Y. TSANG
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. WILLIAM S. BLAKEMORE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SINGH, I., TSANG, K. & BLAKEMORE, W. Immunologic studies in contacts of osteosarcoma in humans and animals. Nature 265, 541–542 (1977). https://doi.org/10.1038/265541a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/265541a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing