Abstract
GENITAL WARTS (condylomata acuminata) are benign tumours which are mostly venereally transmitted1; their malignant conversion has been observed only rarely (see refs 2, 3 for reviews). Typical viral particles, long believed to be those of the human papillomavirus (HPV) found in skin warts4, were observed irregularly in these lesions5–7. Epidemiological1 and serological6 data, as well as molecular hybridisation experiments showing the absence of DNA sequences homologous to skin HPV DNA in condylomas8,9, have raised the possibility that these lesions are due to a distinct HPV. However, the demonstration of at least four distinct HPV types in skin lesions10–13 requires a reexamination of this problem. We have identified four types of HPV showing little, if any, DNA sequence homology and distinct serological properties: HPV type 1 (HPV-1) associated with deep plantar warts12, HPV type 2 (HPV-2) isolated from common warts12, HPV type 3 (HPV-3) found in flat warts and in flat wart-like lesions of patients suffering from epidermodysplasia verruciformis (EV)13 and HPV type 4 (HPV-4) isolated from morphologically distinct EV lesions (reddish or pityriasis versicolor-like plaques)13. HPV-4 is found more frequently than HPV-3 in patients with EV showing a malignant conversion of some lesions13,22. We report here RNA–DNA hybridisation data indicating that genital warts are associated with an HPV showing little, if any, DNA sequence homology with HPV-1, HPV-2 and HPV-3 and a low extent of homology with an HPV-4 isolate taken as prototype in previous studies13.
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ORTH, G., FAVRE, M., JABLONSKA, S. et al. Viral sequences related to a human skin papillomavirus in genital warts. Nature 275, 334–336 (1978). https://doi.org/10.1038/275334a0
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DOI: https://doi.org/10.1038/275334a0
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