Abstract
The mechanism of β-adrenergic relaxation was investigated in isolated smooth muscle cells. β-adrenergic agents stimulate cyclic AMP-dependent phosphorylation, enhance Na+/K+ transport and induce relaxation. The stimulation of Na+/K+ transport is obligatory for relaxation, and we suggest that this stimulation induces relaxation through enhanced Na+/Ca2+ exchange.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dixon, W. E. J. Physiol., Lond., 30, 97–131 (1903).
Hoskins, R. G. Am. J. Physiol. 29, 363–366 (1911–12).
Sutherland, E. W. & Rall, T. W. J. biol. Chem. 232, 1077–1091 (1957).
Robison, G. A., Butcher, R. W. & Sutherland, E. W. Cyclic AMP (Academic, New York, 1971).
Rubin, C. S. & Rosen, O. M. A. Rev. Biochem. 44, 831–887 (1975).
Krebs, E. G. Curr. Topics Cell Regulation 5, 99–133 (1972).
Nimmo, H. G. & Cohen, P. Adv. Cyclic Nucleotide Res. 8, 145–247 (1977).
Schultz, G. & Hardman, J. G. in Regulation of Function and Growth of Eukaryotic Cells by Intracellular Cyclic Nucleotides (eds Dumont, J. E., Butcher, R. W. & Brown, B.) (Plenum, New York, 1975).
Andersson, R. et al. Adv. Cyclic Nudeotide Res. 5, 491–518 (1975).
Bohr, D. R. Pharmac. Rev. 16, 85–111 (1964).
Somlyo, A. P. & Somlyo, A. V. Pharmac. Rev. 20, 197–272 (1968).
Marshall, J. M. & Kroeger, E. A. Phil. Trans. R. Soc. Lond. B265, 135–148 (1973).
Diamond, J. & Holmes, T. G. Can. J. Physiol. Pharmac. 53, 1099–1107 (1975).
Kroeger, E. A. & Marshall, J. M. Am. J. Physiol. 226, 1298–1303 (1974).
Birnbaum, J. E., Abel, P. W., Amidon, G. L. & Buchner, C. K. J. Pharmac. Exp. Ther. 194, 396–409 (1975).
Born, G. V. R. & Bülbring, E. J. Physiol., Lond. 131, 690–703 (1956).
Daniel, E. E., Paton, D. M., Taylor, G. S. & Hodgson, B. J. Fedn Proc. 29, 1410–1425 (1970).
Bose, R. & Bose, D. Am. J. Physiol. 233, C8–C13 (1977).
Somlyo, A. & Somlyo, A. V. Fedn Proc. 28, 1634–1648 (1969).
Schild, H. O. Br. J. Pharmac. Chemother. 31, 578–592 (1967).
Bülbring, E. & Kuriyama, H. Phil. Trans. R. Soc. Lond. B265, 115–121 (1973).
Kroeger, E. A., Marshall, J. M. & Bianchi, P. J. Pharmac. Exp. Ther. 193, 309–316 (1975).
Jenkinson, D. H. & Morton, I. K. M. J. Physiol., Lond. 188, 387–402 (1967).
Fay, F. S. Nature 265, 553–556 (1977).
Fay, F. S. & Delise, C. M. Proc. natn. Acad. Sci. U.S.A. 70, 641–645 (1973).
Honeyman, T., Merriam, P. & Fay, F. S. Molec. Pharmac. 14, 86–98 (1978).
Fay, F. S. & Singer, J. J. Am. J. Physiol. 232, C144–C154 (1977).
Murray, J. J., Reed, P. W. Fay, F. S. Proc. natn. Acad. Sci. U.S.A. 72, 4459–4463 (1975).
Fay, F. S. & Taylor, S. R. Biophys. J. 21, 184a (1978).
Singer, J. J. & Walsh, J. V. in Excitation–Contraction Coupling in Smooth Muscle (eds Casteels, R., Godfraind, T. & Rüegg, J. C. ) (Elsevier, Amsterdam, 1977).
Walsh, J. V. & J. J. Singer, Nature (submitted).
Corbin, J. D., Keely, S. L. & Park, C. R. J. biol. Chem. 250, 218–225 (1975).
Corbin, J. D., Soderling, T. R. & Park, C. R. J. biol. Chem. 248, 1813–1821 (1973).
Bueding, E., Bülbring, E., Gercken, G., Hawkins, J. T. & Kuriyama, H. J. Physiol., Lond. 193, 187–212 (1967).
Yoshimura, K. J. Biochem. 74, 389–391 (1973).
Rogus, M., Cheng, L. C. & Zierler, K. Biochim. Biophys. Acta 464, 347–355 (1977).
St. Louis, P. J. & Sulakhe, P. V. Eur. J. Pharmac. 43, 277–280 (1977).
Braughler, J. M. & Corder, C. N. Biochim. Biophys. Acta 524, 455–465 (1978).
Burnstock, G. J. Physiol., Lond., 143, 183–194 (1958).
Casteels, R., Droogmans, G. & Hendrickx, H. J. Physiol., Lond. 217, 297–313 (1971).
El-Sharkawy, T. Y. & Daniel, E. E. Am. J. Physiol. 229, 1277–1286 (1975).
Marshall, J. M. Fedn. Proc. 36, 2450–2455 (1977).
Brading, A. F. & Widdicombe, J. H. in Colloquium on Smooth Muscle, Pharmacology and Physiology (eds Worcel, M. & Vassort, G. ) (INSERM, Paris, 1976).
Reuter, H., Blaustein, M. P. & Haeusler, G. Phil. Trans. R. Soc. Lond. B265, 87–94 (1974).
Blaustein, M. P. Am. J. Physiol. 232, C165–C173 (1977).
Ma, T. S. & Bose, D. Am. J. Physiol. 232, C59–C66 (1977).
Singer, J. J. & Fay, F. S. Am. J. Physiol. 232, C138–C143 (1977).
Gilman, A. G. Proc. natn. Acad. Sci. U.S.A. 67, 305–312 (1970).
Hardman, J. G., Mayer, S. E. & Clark, B. J. Pharmac. exp. Ther. 150, 341–348 (1965).
Keynes, R. D. Proc. R. Soc. Lond. 142, 359–382 (1954).
Rubin, C. S., Erlichman, J. & Rosen, O. M. Meth. Enzym. 38, 308–315 (1974).
Ray, T. K. & Forte, J. G. Biochim. biophys. Acta 443, 451–467 (1976).
Schwartz, A., Lindenmayer, G. E. & Allen, J. C. Pharmac. Rev. 27, 3–134 (1975).
Jorgensen, P. L. Q. Rev. Biophys. 7, 239–274 (1975).
Schwartz, A., Allen, J. C. & Harigay, S. J. Pharmac. Exp. Ther. 168, 31–41 (1969).
Walsh et al. J. biol. Chem. 246, 177–185 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Scheid, C., Honeyman, T. & Fay, F. Mechanism of β- adrenergic relaxation of smooth muscle. Nature 277, 32–36 (1979). https://doi.org/10.1038/277032a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/277032a0
This article is cited by
-
Influence of GRK5 gene polymorphisms on ritodrine efficacy and adverse drug events in preterm labor treatment
Scientific Reports (2020)
-
Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study
European Journal of Clinical Pharmacology (2019)
-
β-Adrenoceptors, but not dopamine receptors, mediate dopamine-induced ion transport in late distal colon of rats
Cell and Tissue Research (2008)
-
β-Adrenoceptor mediated responses in rat pulmonary artery: putative role of TASK-1 related K channels
Naunyn-Schmiedeberg's Archives of Pharmacology (2006)
-
Neuronally released (?)-noradrenaline relaxes smooth muscle of calf trachea mainly through ?1-adrenoceptors : comparison with (?)-adrenaline and relation to adenylate cyclase stimulation
Naunyn-Schmiedeberg's Archives of Pharmacology (2004)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.