Francis Rolleston proposes a formula to bridge the safety gap in recombinant DNA research and concludes that any approach which falls short calculation of the risks is necessarily misleading.
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Rolleston, F. ‘There is a frustrating logical gap between the assertion that recombinant DNA poses potential risks … and the containment levels imposed by current guidelines’. Nature 281, 626–627 (1979). https://doi.org/10.1038/281626a0
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DOI: https://doi.org/10.1038/281626a0