Abstract
In the wild, organisms generally allocate their time among many behavioural tendencies in response to both current and anticipated motivational requirements1. However, activities that are apparently ‘irrelevant’ often intrude, either during conflict between these behavioural tendencies, or when a strong tendency is thwarted. These ‘irrelevant’ activities are called displacement behaviours and are widely documented in the ethological literature2,3. We report here that an experimental analogue of displacement behaviour in the rat depends upon the integrity of the mesolimbic dopaminergic projection to the nucleus accumbens septi, olfactory tubercle and associated structures of the forebrain4–6.
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References
McFarland, D. J. in Advances in the Study of Animal Behaviour Vol. 5 (eds Lehrman, D. S., Hinde, R. H. & Shaw, E.) 201–225 (Academic, London, 1974).
Tinbergen, N. E. Q. Rev. Biol. 27, 1–32 (1952).
Hinde, R. A. Animal Behaviour: a Synthesis of Ethology and Comparative Psychology (McGraw-Hill, New York, 1966).
Lindvall, O. & Bjorklund, A. in Handbook of Psychopharmacology Vol. 9 (eds Iversen, L. L., Iversen, S. D. & Snyder, S. H.) 139–231 (Plenum, New York, 1978).
Fallon, J. H. & Moore, R. Y. J. comp. Neurol. 180, 545–580 (1978).
Simon, H., Le Moal, M., Galey, D. & Cardo, B. Brain Res. 115, 215–231 (1976).
Falk, J. L. Physiol. Behav. 6, 577–588 (1971).
Staddon, J. E. R. & Simmelhag, V. L. Psychol. Rev. 78, 3–43 (1971).
Kachanoff, R., Leveille, R., McClelland, J. P. & Wayner, M. J. Physiol. Behav. 11, 395–398 (1973).
Killeen, P. R., Hanson, S. J. & Osbourne, S. R. Psych. Rev. 85, 571–581 (1978).
Wallace, M. & Singer, G. Pharmac. Biochem. Behav. 5, 483–490 (1976).
Wayner, M. J. Physiol. Behav. 5, 1319–1325 (1970).
Cantor, M. B. & Wilson, J. F. Learn Motiv. 9, 428–445 (1978).
Falk, J. L. in Thirst (ed. Wayner, M. J.) 95–113 (Pergamon, New York, 1964).
Teitelbaum, P. & Epstein, A. N. Psych. Rev. 69, 74–90 (1962).
Ungerstedt, U. Acta physiol. scand. Suppl. 367, 95–122 (1971).
Koob, G. F., Riley, S. J., Smith, S. C. & Robbins, T. W. J. comp. Physiol. Psychol. 92, 651–660 (1978).
Pellegrino, L. J. & Cushman, A. J. A Stereotaxic Atlas of Rat Brain (Appleton-Century-Crofts, New York, 1967).
Breese, G. R. & Traylor, T. D. Br. J. Pharmac. 42, 88–89 (1972).
Coyle, J. T. & Henry, D. J. Neurochem. 21, 61–67 (1973).
Sailer, C. F. & Zigmond, M. J. Life Sci. 23, 1117–1130 (1978).
Hendry, I. A. & Iversen, L. L. Brain Res. 29, 159–162 (1971).
Sanger, D. J. & Blackman, D. E. in Contemporary Research in Behavioural Pharmacology (ed. Blackman, D. E. & Sanger, D. J.) 239–287 (Plenum, New York, 1978).
Winer, B. J. Statistical Principles in Experimental Design 2nd edn (McGraw-Hill, New York, 1971).
Jones, D. L. & Mogenson, G. J. Eur. J. Pharmac. 59, 11–21 (1979).
Robbins, T. W. Neurosci. Lett. S58, Suppl. 1 (1978).
Kelly, P. H., Seviour, P. & Iversen, S. D. Brain Res. 94, 507–522 (1975).
Devenport, L. D. J. comp. physiol. Psychol. 92, 651–660 (1978).
Skinner, B. F. & Morse, W. H. J. comp. physiol. Psychol. 50, 279–281 (1957).
Holland, H. C. in Obsessional States (ed. Beech, H. R.) 161–173 (Methuen, London, 1974).
Thierry, A. M., Tassin, J. P., Blanc, G. & Glowinski, J. Nature 263, 242–244 (1976).
Price, K. A., Farley, I. J. & Hornykiewicz, O. in Dopamine (eds Rogers, P. J., Woodruff, G. N. & Iversen, L. L.) 293–300 (Raven, New York, 1978).
Stevens, J. R. Archs gen Psychiat. 29, 177–189 (1973).
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Robbins, T., Koob, G. Selective disruption of displacement behaviour by lesions of the mesolimbic dopamine system. Nature 285, 409–412 (1980). https://doi.org/10.1038/285409a0
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DOI: https://doi.org/10.1038/285409a0
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