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A novel human lymphokine that inhibits haematopoietic progenitor cell proliferation

Nature volume 309, pages 166–168 (1984)Cite this article

Abstract

T lymphocytes in culture synthesize and secrete a variety of factors1–6 that activate and guide the differentiation3,4, replication5 and maturation5 of haematopoietic cells in vitro. Malignant T-cell lines as well as T-cell hybridomas producing several of these factors have been established5–13. We report here a factor produced by a human cell line that exerts a potent inhibitory effect on the growth of bone marrow progenitor cells. The properties of this factor, which we have termed colony-inhibiting lymphokine (CIL), differ from other inhibitors of haematopoietic progenitor cell proliferation, but resemble those of a T-cell-derived factor causally linked with some cases of severe aplastic anaemia in humans14. Sensitivity of cells to this factor appears to correlate positively with expression of HLA-DR surface antigens.

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References

  1. Chervenick, P. A. & LoBuglio, A. F. Science 178, 169–170 (1972).

    Article  ADS  Google Scholar 

  2. Porter, J. W. & Metcalf, D. J. J. Immun. 112, 504–510 (1974).

    Google Scholar 

  3. Olsson, J., Olofsson, T. & Mauritzon, N. J. natn. Cancer Inst. 67, 1225–1231 (1981).

    CAS  Google Scholar 

  4. Iscove, N. N., Rotsch, C. A., Williams, N. & Guilbert, L. J. J. cell. Physiol. (Suppl.) 1, 65–73 (1982).

    Article  CAS  Google Scholar 

  5. Lernhardt, W., Corbel, C., Wall, R. & Melchers, F. Nature 300, 355–356 (1982).

    Article  CAS  ADS  PubMed  Google Scholar 

  6. Waksman, B. H. in The Biology of the Lymphokines (eds Cohen, S., Dick, E. & Oppenheim, J. J.) 585–613 (Academic, New York, 1979).

    Book  Google Scholar 

  7. DeFreitas, E. et al., Proc. natn. Acad. Sci. U.S.A. 79, 6646–6650 (1982).

    Article  CAS  ADS  Google Scholar 

  8. Gillis, S. & Watson, J. J. exp. Med. 152, 1709–1719 (1980).

    Article  CAS  PubMed  Google Scholar 

  9. DiPersio, J. F., Brennan, J. K., Lightman, M. & Speiser, B. L. Blood 51, 507–519 (1978).

    CAS  Google Scholar 

  10. Von Boehmer, H., Haas, W., Kohler, G., Melchers, F. & Zeuthen, J. Curr. Topics Microbiol. Immun. 100, 5–320 (1982).

    Google Scholar 

  11. Grillot-Courvalin, C., Brovet, J. C., Berger, R. & Bernheim, A. Nature 292, 844–845 (1981).

    Article  CAS  ADS  PubMed  Google Scholar 

  12. Kobayashi, Y., Asada, M., Higuchi, M. & Osawa, T. J. Immun. 128, 2714–2719 (1982).

    CAS  PubMed  Google Scholar 

  13. Okada, M., Yoshimura, N., Kaieda, T., Yamamura, Y. & Kishimoto, T. Proc. natn. Acad. Sci. U.S.A. 78, 7717–7726 (1981).

    Article  CAS  ADS  Google Scholar 

  14. Bacigalupo, A. et al. J. Immun. 125, 1449–1452 (1980).

    CAS  PubMed  Google Scholar 

  15. Trucco, M., Garotta, G., Stocker, J. W. & Ceppellini, R. Immun. Rev. 47, 219–252 (1979).

    Article  CAS  PubMed  Google Scholar 

  16. Foung, S., Sasaki, D. T., Grumet, F. C. & Engleman, E. Proc. natn. Acad. Sci. U.S.A. 79, 7484–7489 (1982).

    Article  CAS  ADS  Google Scholar 

  17. Iscove, N. N., Senn, J. S., Till, J. E. & McCulloch, E. A. Blood 37, 1–5 (1971).

    CAS  PubMed  Google Scholar 

  18. Johnson, G. R., Dresch, C. & Metcalf, D. Blood 50, 823–831 (1977).

    CAS  PubMed  Google Scholar 

  19. Ferrero, D. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4114–4119 (1983).

    Article  CAS  ADS  Google Scholar 

  20. Ferrero, D. & Rovera, G. in Clinics in Hematology (ed. McCulloch, E. A.) Vol. 13, 461–487 (W. B. Saunders, London, 1984).

    Google Scholar 

  21. Pelus, L. M. J. clin. Invest. 70, 568–578 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Broxmeyer, H. E. J. clin. Invest. 69, 632–642 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Lu, L., Broxmeyer, H. E., Meyers, P. A., Moore, M. A. & Thaler, H. T. Blood 61, 250–256 (1983).

    CAS  PubMed  Google Scholar 

  24. Reinherz, E. L. & Schlossman, S. F. Cell 19, 821–826 (1980).

    Article  CAS  PubMed  Google Scholar 

  25. Broxmeyer, H. E., Shithyman, A., Eger, R. R., Meyers, P. A. & deSousa, M. J. exp. Med. 148, 1052–1063 (1978).

    Article  CAS  PubMed  Google Scholar 

  26. Kurland, J., Backman, R., Broxmeyer, H. E. Moore, M. Science 199, 552–553 (1978).

    Article  CAS  ADS  PubMed  Google Scholar 

  27. Broxymeyer, H. E., Bognati, T., Dorner, M. H. & deSousa, M. J. exp. Med. 153, 1426–1444 (1981).

    Article  Google Scholar 

  28. Greenberg, P. L. & Mosny, S. A. Cancer Res. 37, 1794–1799 (1977).

    CAS  PubMed  Google Scholar 

  29. Santoli, D. et al., J. Immun. 126, 1274–1278 (1981).

    CAS  PubMed  Google Scholar 

  30. Bacigalupo, A. et al. Blood 57, 491–496 (1981).

    CAS  PubMed  Google Scholar 

  31. Ash, R. C., Detrick, R. A. & Zanjani, E. D. Blood 58, 309–316 (1981).

    CAS  PubMed  Google Scholar 

  32. Tepperman, A. D., Curtis, J. E. & McCulloch, E. A. Blood 44, 659–669 (1974).

    CAS  PubMed  Google Scholar 

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Author notes

  1. Dario Ferrero

    Present address: Department of Haematology, University of Turin, Ospedale S. Giovanni, Torino, Italy

Authors and Affiliations

  1. Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania, 19104, USA

    Massimo Trucco, Giovanni Rovera & Dario Ferrero

Authors
  1. Massimo Trucco
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  2. Giovanni Rovera
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  3. Dario Ferrero
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Trucco, M., Rovera, G. & Ferrero, D. A novel human lymphokine that inhibits haematopoietic progenitor cell proliferation. Nature 309, 166–168 (1984). https://doi.org/10.1038/309166a0

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