Abstract
The five membrane-spanning subunits of the acetylcholine receptor have been resolved in electron microscope images and are shown to lie at pentagonally symmetrical positions around the channel over a large fraction of their length. The channel consists of a wide synaptic portion and a narrow portion extending through the membrane into the interior of the cell.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Changeux, J.-P. Harvey Lect. 75, 85–254 (1980).
Karlin, A. in The Cell Surface and Neuronal Function (eds Cotman, C. W., Poste, G. & Nicolson, G. L.) 191–260 (North-Holland, Amsterdam, 1980).
Conti-Tronconi, B. M. & Raftery, M. A. A. Rev. Biochem. 51, 491–530 (1982).
Noda, M. et al. Nature 299, 793–797 (1982).
Noda, N. et al. Nature 301, 251–255 (1983).
Claudio, T., Ballivet, M., Patrick, J. & Heinemann, S. Proc. nat. Acad. Sci. U.S.A. 80, 1111–1115 (1983).
Devillers-Thiery, A., Giraudat, J., Bentaboulet, M. & Changeux, J.-P. Proc. nat. Acad. Sci U.S.A. 80, 2067–2071 (1983).
Popot, J.-L. & Changeux, J.-P. Physiol. Rev. 64, 1162–1239 (1984).
Noda, et al. Nature 302, 528–532 (1983).
Finer-Moore, J. & Stroud, R. M. Proc. natn. Acad. Sci. U.S.A. 81, 155–159 (1984).
Lewis, C. A. & Stevens, C. F. Proc. natn. Acad. Sci. U.S.A. 80, 6110–6113 (1983).
Guy, H. R. Biophys. J. 45, 249–261 (1984).
Brisson, A. & Unwin, P. N. T. J. Cell Biol. 99, 1202–1211 (1984).
Amos, L. A., Henderson, R. & Unwin, P. N. T. Prog. Biophys. molec. Biol. 39, 183–231 (1982).
Finch, J. T. & Klug, A. J. molec. Biol. 13, 1–12 (1965).
Cartaud, J., Benedetti, E. L., Sobel, A. & Changeux, J.-P. J. Cell Sci. 29, 313–337 (1978).
Sealock, R. J. Cell Biol. 92, 514–522 (1982).
Klymkowsky, M. W. & Stroud, R. M. J. molec. Biol. 128, 319–334 (1979).
Wise, D., Karlin, A. & Schoenborn, B. P. Biophys. J. 28, 473–496 (1979).
Froehner, S. C. et al. Proc. nat. Acad. Sci. U.S.A. 78, 5230–5234 (1981).
Henderson, R. & Unwin, P. N. T. Nature 257, 28–32 (1975).
Agard, D. A. J. molec. Biol. 167, 849–852 (1983).
Dubochet, J., Lepault, J., Freeman, R., Berriman, J. A. & Homo, J.-C. J. Microsc. 128, 219–237 (1982).
Thon, F. Z. Naturforsch. 219, 476–478 (1966).
Kistler, J. K. & Stroud, R. M. Proc. natn. Acad. Sci. U.S.A. 78, 3678–3689 (1981).
Zingsheim, H. P., Neugebauer, D.-C., Barrantes, F. J. & Frank, J. Proc. natn. Acad. Sci. U.S.A. 77, 952–956 (1980).
Bon, F. et al. J. molec. Biol. 176, 205–237 (1984).
Criado, M., Hochschwender, S., Sarin, V., Fox, J. L. & Lindstrom, J. Proc. natn. Acad. Sci. U.S.A. 82, 2004–2008 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brisson, A., Unwin, P. Quaternary structure of the acetylcholine receptor. Nature 315, 474–477 (1985). https://doi.org/10.1038/315474a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/315474a0
This article is cited by
-
Direct recording and molecular identification of the calcium channel of primary cilia
Nature (2013)
-
Structural and functional crosstalk between acetylcholine receptor and its membrane environment
Molecular Neurobiology (1992)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.