Abstract
A class I histocompatibility gene, H-2Kb, linked to the rat insulin promoter, is overexpressed in the pancreatic β cells of transgenic mice. The mice, whether syngeneic or allogeneic to the transgene, develop insulin dependent diabetes without detectable T cell infiltration, suggesting a direct, non-immune role for the transgenic class I molecules in the disease process.
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Allison, J., Campbell, I., Morahan, G. et al. Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells. Nature 333, 529–533 (1988). https://doi.org/10.1038/333529a0
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DOI: https://doi.org/10.1038/333529a0
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