Abstract
A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a century, but only recently have experimental systems and methods of analysis progressed to the point where we begin to understand how a cell can sense and respond to tiny changes in minute concentrations of extracellular signalling factors.
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Acknowledgements
We apologize to the authors of original work not cited. Owing to space limitations, we cited review articles where possible. Our work is supported by the Cancer Research Campaign and the European Community.
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Gurdon, J., Bourillot, PY. Morphogen gradient interpretation. Nature 413, 797–803 (2001). https://doi.org/10.1038/35101500
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DOI: https://doi.org/10.1038/35101500
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