A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution.
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Rothman, J., Orci, L. Molecular dissection of the secretory pathway. Nature 355, 409–415 (1992). https://doi.org/10.1038/355409a0
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DOI: https://doi.org/10.1038/355409a0
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