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Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

Nature volume 357, pages 211–215 (1992)Cite this article

Abstract

Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with an altered spectrum of bound peptides.

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Author notes

  1. Antonio Ciruela

    Present address: Biological Laboratory, University of Kent, Canterbury, CT2 7NJ, UK

Authors and Affiliations

  1. Department of Immunology, Agricultural and Food Research Council Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, CB2 4AT, UK

    Simon J. Powis, Edward V. Deverson, W. John Coadweil, Antonio Ciruela, Neville S. Huskisson, Howard Smith, Geoffrey W. Butcher & Jonathan C. Howard

  2. Microchemical Facility, Agricultural and Food Research Council Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, CB2 4AT, UK

    Antonio Ciruela & Neville S. Huskisson

Authors
  1. Simon J. Powis
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  2. Edward V. Deverson
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  3. W. John Coadweil
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  4. Antonio Ciruela
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  5. Neville S. Huskisson
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  6. Howard Smith
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  7. Geoffrey W. Butcher
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  8. Jonathan C. Howard
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Powis, S., Deverson, E., Coadweil, W. et al. Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature 357, 211–215 (1992). https://doi.org/10.1038/357211a0

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