Abstract
CALCIUM influx through voltage-sensitive Ca2+ channels is the normal physiological stimulus for the activity-dependent release of neurotransmitters at synaptic contacts. It has been postulated that presynaptic inhibition of transmitter release is due to a reduction in Ca2+ influx at the nerve terminal, which could result from the direct inhibition of Ca2+ channels. Neuropeptide Y and noradren-aline act as cotransmitters at many sympathetic synapses. Both of these substances produce presynaptic inhibition and can inhibit Ca2+ currents in the soma of sympathetic neurons1–5. Here we provide direct evidence that presynaptic inhibition produced by neuropeptide Y at sympathetic nerve terminals is associated with a reduction in Ca2+ influx and that this is due to the selective inhibition of neuronal N-type Ca2+ channels.
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Toth, P., Bindokas, V., Bleakman, D. et al. Mechanism of presynaptic inhibition by neuropeptide Y at sympathetic nerve terminals. Nature 364, 635–639 (1993). https://doi.org/10.1038/364635a0
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DOI: https://doi.org/10.1038/364635a0
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